Publication: Dietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice
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Issued Date
2014
Resource Type
File Type
application/pdf
ISSN
16134125
Other identifier(s)
2-s2.0-84901947811
Rights Holder(s)
Scopus
Bibliographic Citation
Molecular Nutrition and Food Research. Vol 58, No.6 (2014), p.1226-1238
Suggested Citation
Gutierrez-Orozco F., Thomas-Ahner J.M., Berman-Booty L.D., Galley J.D., Chitchumroonchokchai C., Mace T., Suksamrarn S., Bailey M.T., Clinton S.K., Lesinski G.B., Failla M.L. Dietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice. Molecular Nutrition and Food Research. Vol 58, No.6 (2014), p.1226-1238. doi:10.1002/mnfr.201300771 Retrieved from: https://hdl.handle.net/20.500.14740/6464
Abstract
Scope: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon. α-Mangostin (α-MG), the most abundant xanthone in mangosteen fruit, exerts anti-inflammatory and antibacterial activities in vitro. We evaluated the impact of dietary α-MG on murine experimental colitis and on the gut microbiota of healthy mice. Methods and results: Colitis was induced in C57BL/6J mice by administration of dextran sulfate sodium (DSS). Mice were fed control diet or diet with α-MG (0.1%). α-MG exacerbated the pathology of DSS-induced colitis. Mice fed diet with α-MG had greater colonic inflammation and injury, as well as greater infiltration of CD3+ and F4/80+ cells, and colonic myeloperoxidase, than controls. Serum levels of granulocyte colony-stimulating factor, IL-6, and serum amyloid A were also greater in α-MG-fed animals than in controls. The colonic and cecal microbiota of healthy mice fed α-MG but no DSS shifted to an increased abundance of Proteobacteria and decreased abundance of Firmicutes and Bacteroidetes, a profile similar to that found in human UC. Conclusion: α-MG exacerbated colonic pathology during DSS-induced colitis. These effects may be associated with an induction of intestinal dysbiosis by α-MG. Our results suggest that the use of α-MG-containing supplements by patients with UC may have unintentional risk. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Subject(s)
Amyloid
Dextran sulfate
Interleukin 6
Mangostin
Peroxidase
Xanthone derivative
Animal
Blood
C57BL mouse
Chemically induced
Chemistry
Colon
Diet
Diet supplementation
Disease model
Drug effects
Dysbiosis
Enzymology
Female
Fruit
Garcinia mangostana
Isolation and purification
Metabolism
Microbiology
Mouse
Pathology
Proteobacteria
Ulcerative colitis
Amyloid
Animals
Colitis, Ulcerative
Colon
Dextran Sulfate
Diet
Dietary Supplements
Disease Models, Animal
Dysbiosis
Female
Fruit
Garcinia mangostana
Interleukin-6
Mice
Mice, Inbred C57BL
Peroxidase
Proteobacteria
Xanthones
Dextran sulfate
Interleukin 6
Mangostin
Peroxidase
Xanthone derivative
Animal
Blood
C57BL mouse
Chemically induced
Chemistry
Colon
Diet
Diet supplementation
Disease model
Drug effects
Dysbiosis
Enzymology
Female
Fruit
Garcinia mangostana
Isolation and purification
Metabolism
Microbiology
Mouse
Pathology
Proteobacteria
Ulcerative colitis
Amyloid
Animals
Colitis, Ulcerative
Colon
Dextran Sulfate
Diet
Dietary Supplements
Disease Models, Animal
Dysbiosis
Female
Fruit
Garcinia mangostana
Interleukin-6
Mice
Mice, Inbred C57BL
Peroxidase
Proteobacteria
Xanthones