Publication: Clinical efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel in treatment of mild-to-moderate acne vulgaris: A 12-week, split-face, double-blinded, randomized, controlled trial
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Issued Date
2019
Resource Type
File Type
application/pdf
ISSN
14732130
Other identifier(s)
2-s2.0-85060706285
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Journal of Cosmetic Dermatology. Vol 18, No.5 (2019), p.1395-1403
Suggested Citation
Lueangarun S., Sriviriyakul K., Tempark T., Managit C., Sithisarn P. Clinical efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel in treatment of mild-to-moderate acne vulgaris: A 12-week, split-face, double-blinded, randomized, controlled trial. Journal of Cosmetic Dermatology. Vol 18, No.5 (2019), p.1395-1403. doi:10.1111/jocd.12856 Retrieved from: https://hdl.handle.net/20.500.14740/5139
Abstract
Background: Acne vulgaris is the most common inflammatory sebaceous gland disorder in young adults. The resistant strains of Propionibacterium acnes (P. acnes) are of increasing concern in the treatment of acne. Objectives: To evaluate the efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel (containing alpha-mangostin) compared with 1% clindamycin gel for treatment of mild-to-moderate acne vulgaris. Methods: Patients aged 18-40 years were enrolled in this double-blinded, split-face, randomized, control study. The 2.5% benzoyl peroxide cream was applied to both sides of the faces once daily for 5 minutes and washed off. Each patient was randomly treated with the mangosteen fruit rind extract on one side and 1% clindamycin on another side of the face twice daily for 12 weeks. Treatment efficacies and side effects were evaluated on every follow-up. Results: Twenty-eight patients, 24 female (85.7%), mean ± SD age of 25.14 ± 5.8, with Global Acne Grading system (GAGs) score of 15.43 ± 5.96 were included. Mangosteen fruit rind extract significantly showed significant 66.86% and 67.05% reduction of comedone and inflammatory lesions (P < 0.001) after 12-week treatment. The improvement on both treated sides significantly showed since 2 weeks after treatment, without statistical difference between two groups. Nonetheless, the mangosteen fruit rind extract revealed significantly better improvement of clinical severity, with no severe side effects. Conclusions: The mangosteen fruit rind extract formation could be a phytopharmaceutical medication for effective treatment of mild and moderate acne vulgaris treatment comparable to 1% clindamycin gel, with no severe side effects. © 2019 Wiley Periodicals, Inc.
Subject(s)
Benzoyl peroxide
Clindamycin
Garcinia mangostana extract
Nanoparticle
Plant extract
Unclassified drug
Acne vulgaris
Adult
Article
Clinical article
Comedo
Controlled study
Disease severity
Double blind procedure
Drug efficacy
Drug tolerability
Dry skin
Female
Garcinia mangostana
Gel
Human
Male
Patient satisfaction
Priority journal
Pruritus
Randomized controlled trial
Skin defect
Skin irritation
Clindamycin
Garcinia mangostana extract
Nanoparticle
Plant extract
Unclassified drug
Acne vulgaris
Adult
Article
Clinical article
Comedo
Controlled study
Disease severity
Double blind procedure
Drug efficacy
Drug tolerability
Dry skin
Female
Garcinia mangostana
Gel
Human
Male
Patient satisfaction
Priority journal
Pruritus
Randomized controlled trial
Skin defect
Skin irritation