Publication: Efficacy of intravenous ondansetron to prevent vomiting episodes in acute gastroenteritis: A randomized, double blind, and controlled trial
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Issued Date
2010
Resource Type
File Type
application/pdf
ISSN
20367503
Other identifier(s)
2-s2.0-79952576809
Rights Holder(s)
Scopus
Bibliographic Citation
Pediatric Reports. Vol 2, No.2 (2010), p.55-57
Suggested Citation
Rerksuppaphol S., Rerksuppaphol L. Efficacy of intravenous ondansetron to prevent vomiting episodes in acute gastroenteritis: A randomized, double blind, and controlled trial. Pediatric Reports. Vol 2, No.2 (2010), p.55-57. doi:10.4081/pr.2010.e17 Retrieved from: https://hdl.handle.net/20.500.14740/7442
Author(s)
Abstract
Acute gastroenteritis is one of the most common infectious diseases of childhood. Its symptoms are vomiting, diarrhea, and dehydration. In the emergency ward, intravenous rather than oral rehydration is usually preferred because of the high likelihood of emesis. Treatments to reduce emesis are of value in improving the rehydration procedure. Our study is a double-blind randomized trial and proposes the use of ondansetron as an antiemetic drug to treat children with acute gastroenteritis. Seventy-four in-patients, aged 3 months to 15 years, were enrolled and randomly assigned to an ondansetron or placebo group. Inclusion criteria were the diagnosis of acute gastroenteritis and the absence of other diseases or allergies to drugs. A single bolus (0.15 mg/kg) of ondansetron was injected intravenously; normal 0.9% saline solution was used as a placebo. This treatment induced vomiting cessation in the ondansetron group significantly in comparison to the placebo group. The length of the hospital stay and the oral rehydration fluid volume were similar in the two groups and no adverse effects were noticed. Thus, safety, low cost, and overall bene fit of ondansetron treatment suggests that this drug can be administered successfully to children with acute gastroenteritis. © S. Rerksuppaphol and L. Rerksuppaphol 2010.
Subject(s)
Ondansetron
Placebo
Absence of side effects
Acute gastroenteritis
Adolescent
Article
Child
Controlled study
Double blind procedure
Drug cost
Drug safety
Female
Human
Infant
Length of stay
Major clinical study
Male
Oral rehydration therapy
Preschool child
Randomized controlled trial
School child
Single drug dose
Vomiting
Placebo
Absence of side effects
Acute gastroenteritis
Adolescent
Article
Child
Controlled study
Double blind procedure
Drug cost
Drug safety
Female
Human
Infant
Length of stay
Major clinical study
Male
Oral rehydration therapy
Preschool child
Randomized controlled trial
School child
Single drug dose
Vomiting