Publication:
Metal complexes of uracil derivatives with cytotoxicity and superoxide scavenging activity

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Issued Date

2012

Resource Type

Article

File Type

application/pdf

ISSN

15701808

DOI

10.2174/157018012799129918

Other identifier(s)

2-s2.0-84858217824

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Letters in Drug Design and Discovery. Vol 9, No.3 (2012), p.282-287

Suggested Citation

Prachayasittikul S., Worachartcheewan A., Pingaew R., Suksrichavalit T., Isarankura-Na-Ayudhya C., Ruchirawat S., Prachayasittikul V. Metal complexes of uracil derivatives with cytotoxicity and superoxide scavenging activity. Letters in Drug Design and Discovery. Vol 9, No.3 (2012), p.282-287. doi:10.2174/157018012799129918 Retrieved from: https://hdl.handle.net/20.500.14740/7098

Title

Metal complexes of uracil derivatives with cytotoxicity and superoxide scavenging activity

Author(s)

Prachayasittikul S.
 Worachartcheewan A.
 Pingaew R.
 Suksrichavalit T.
 Isarankura-Na-Ayudhya C.
 Ruchirawat S.
 Prachayasittikul V.

Abstract

5-Substituted uracils were reported to be important core structure of diverse therapeutics. Herein, novel mixed ligand transition metal (Mn, Cu, Ni) complexes of 5-iodouracil (5Iu) with 8-hydroxyquinoline or 8HQ (1-3) and 5-nitrouracil (5Nu) with 8HQ (4-6) have been synthesized. The metal complexes 1-6 exert significant cytotoxicity against HepG2, A-549, HuCCA-1 and MOLT-3 cell lines. Particularly, the cytotoxicities of tested complexes against HepG2 cells show their IC 50 values lower than the reference drug. Cu complex of 5Nu (5Nu-Cu-8HQ, 5) is the most potent and promising cytotoxic compound. Mn complex of 5Iu (5Iu-Mn-8HQ, 1) is shown to be the most potent antioxidant. This finding reveals the application of using simple and commercially available bioactive ligands like 5Iu, 5Nu and 8HQ for the design and construction of new lead compounds with significant and promising bioactivities. © 2012 Bentham Science Publishers.

Subject(s)

5 iodouracil 8 hydroxyquinoline copper complex
 5 iodouracil 8 hydroxyquinoline manganese complex
 5 iodouracil 8 hydroxyquinoline nickel complex
 5 nitrouracil 8 hydroxyquinoline copper complex
 5 nitrouracil 8 hydroxyquinoline manganese complex
 5 nitrouracil 8 hydroxyquinoline nickel complex
 8 quinolinol derivative
 Copper complex
 Doxorubicin
 Etoposide
 Fialuridine
 Manganese derivative
 Metal complex
 Nickel complex
 Scavenger
 Superoxide
 Superoxide dismutase
 Unclassified drug
 Uracil derivative
 Acute lymphoblastic leukemia
 Antioxidant activity
 Article
 Bile duct carcinoma
 Cancer cell culture
 Cell strain HepG2
 Controlled study
 Cytotoxicity
 Drug potency
 Drug structure
 Drug synthesis
 Human
 Human tissue
 Lung carcinoma
 Priority journal

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URI

https://hdl.handle.net/20.500.14740/7098

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Scopus: Year 1983-2021

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