Publication:
Prevalence of human papillomavirus genotypes in cervical cancer

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Issued Date

2012

Resource Type

Article

File Type

application/pdf

ISSN

1048891X

DOI

10.1097/IGC.0b013e318259d904

Other identifier(s)

2-s2.0-84863628026

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

International Journal of Gynecological Cancer. Vol 22, No.6 (2012), p.1063-1068

Suggested Citation

Chinchai T., Chansaenroj J., Swangvaree S., Junyangdikul P., Poovorawan Y. Prevalence of human papillomavirus genotypes in cervical cancer. International Journal of Gynecological Cancer. Vol 22, No.6 (2012), p.1063-1068. doi:10.1097/IGC.0b013e318259d904 Retrieved from: https://hdl.handle.net/20.500.14740/7021

Title

Prevalence of human papillomavirus genotypes in cervical cancer

Author(s)

Chinchai T.
 Chansaenroj J.
 Swangvaree S.
 Junyangdikul P.
 Poovorawan Y.

Abstract

Background and Objective: Cervical cancer is the second most common female genital cancer worldwide. There is strong epidemiological and molecular evidence indicating that human papillomavirus (HPV) infection is a necessary event in the development of cervical intraepithelial lesion and subsequent invasive carcinoma. The aim of this study was to investigate the HPV genotype distribution and prevalence in cervical cancer of Thai women. Materials and Methods: One hundred fifty-five cervical cancer specimens were enrolled in this study. The HPV genotypes were determined by means of the combined use of a line probe assay (INNO-LiPA) and DNA chip methods. Results: Of the overall prevalence of HPV in the study group, 83.2% and 11.6% of the cases had single and multiple genotype infections, respectively. The most prevalent genotypes were HPV 16 (51%), followed by HPV 18 (20%), HPV 52 (10.3%), HPV 58 (5.8%), and HPV 33 (4.5%). All HPV genotypes found in this study could be classified as 13 highrisk HPV, 2 low-risk HPV, and 2 additional types. Of the specimens, 94.8% had at least one high-risk HPV genotype infection. Conclusion: As for the potential benefits of commercially available prophylactic vaccines to prevent HPV infection in Thailand, both vaccines (bivalent and quadrivalent) can protect from HPV-related cervical cancer in only approximately 71%. Therefore, screening programs such as routine Papanicolaou test, cytology, and HPV DNA detection are still essential for cervical cancer prevention. Moreover, future generations of HPV vaccines should also include the other most common genotypes and decrease the severe adverse effects reported at the present time. Copyright © 2012 by IGCS and ESGO.

Subject(s)

Virus DNA
 Adult
 Aged
 Article
 Cancer prevention
 Cancer staging
 Cytology
 DNA microarray
 Female
 Genotype
 Human
 Human papillomavirus type 16
 Human papillomavirus type 18
 Human papillomavirus type 33
 Human papillomavirus type 52
 Human papillomavirus type 58
 Major clinical study
 Nonhuman
 Papanicolaou test
 Prevalence
 Priority journal
 Thailand
 Uterine cervix cancer
 Verruca vulgaris
 Wart virus
 Adult
 Aged
 Aged, 80 and over
 Alphapapillomavirus
 Female
 Genotyping Techniques
 Humans
 Middle Aged
 Papillomavirus Infections
 Thailand
 Uterine Cervical Neoplasms

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URI

https://hdl.handle.net/20.500.14740/7021

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Scopus: Year 1983-2021

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