Publication: A new α-pyrone derivative from Annulohypoxylon stygium SWUF09-030
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Issued Date
2021
Resource Type
File Type
application/pdf
ISSN
10286020
Other identifier(s)
2-s2.0-85097763387
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Journal of Asian Natural Products Research. Vol 23, No.12 (2021), p.1182-1188
Suggested Citation
Pimjuk P., Mongkolthanaruk W., Suwannasai N., Senawong T., Tontapha S., Amornkitbumrung V., Mccloskey S. A new α-pyrone derivative from Annulohypoxylon stygium SWUF09-030. Journal of Asian Natural Products Research. Vol 23, No.12 (2021), p.1182-1188. doi:10.1080/10286020.2020.1856095 Retrieved from: https://hdl.handle.net/20.500.14740/8122
Abstract
A new α-pyrone derivative, namely annulopyronoate (1), together with the known isobenzofuranone, diphenyl ether, sesquiterpene, phenolic and diketopiperazine derivatives (2–12) were isolated from a filamentous fungus Annulohypoxylon stygium SWUF09-030. The structures were determined by analysis of spectroscopic and MS data. The absolute configuration of 1 was determined by comparison of experimental and calculated Electronic Circular Dichroism (ECD) spectra. Compounds 3–5 and 7 exhibited both anti-proliferative effects against HeLa, HT29, HCT116, MCF-7 and Vero cell lines and inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. © 2020 Informa UK Limited, trading as Taylor & Francis Group.