Publication:
Attenuation of paraquat-induced motor behavior and neurochemical disturbances by L-valine in vivo

2
0

Issued Date

2004

Resource Type

Article

File Type

application/pdf

ISSN

3784274

DOI

10.1016/j.toxlet.2004.02.007

Other identifier(s)

2-s2.0-1942517470

Rights Holder(s)

Scopus

Bibliographic Citation

Toxicology Letters. Vol 150, No.3 (2004), p.259-269

Suggested Citation

Chanyachukul T., Yoovathaworn K., Thongsaard W., Chongthammakun S., Navasumrit P., Satayavivad J. Attenuation of paraquat-induced motor behavior and neurochemical disturbances by L-valine in vivo. Toxicology Letters. Vol 150, No.3 (2004), p.259-269. doi:10.1016/j.toxlet.2004.02.007 Retrieved from: https://hdl.handle.net/20.500.14740/6411

Title

Attenuation of paraquat-induced motor behavior and neurochemical disturbances by L-valine in vivo

Author(s)

Chanyachukul T.
 Yoovathaworn K.
 Thongsaard W.
 Chongthammakun S.
 Navasumrit P.
 Satayavivad J.

Abstract

Alterations of motor behavioral patterns and monoamine contents in the discrete rat brain areas after acute paraquat exposure (3, 5, 10, 20mg/kg, s.c.) have been studied. The results showed that paraquat at the doses of 5, 10, and 20mg/kg significantly reduced locomotive, stereotypic, and rotational behaviors. Significant decreases of norepinephrine (NE) contents in cortex and hypothalamus, as well as striatal contents of dopamine (DA) and its acidic metabolites, were detected. In addition, L-valine (200mg/kg, i.p.) significantly attenuated paraquat-induced toxicity at moderate dose (5mg/kg) but not at high dose (20mg/kg). The results provide evidence that paraquat can enter the brain as illustrated by the alterations in the motor behavioral pattern and neurochemical contents. Furthermore, the attenuation effect of L-valine against systemic administration of paraquat-induced motor behaviors was detected, with a slightly protective effect on paraquat-induced neurochemical alterations. © 2004 Elsevier Ireland Ltd. All rights reserved.

Subject(s)

Dopamine
 Monoamine
 Noradrenalin
 Paraquat
 Valine
 Animal behavior
 Animal experiment
 Animal model
 Animal tissue
 Article
 Attenuation
 Brain cortex
 Brain level
 Controlled study
 Dopamine brain level
 Dose response
 Drug effect
 Hypothalamus
 Locomotion
 Male
 Metabolite
 Motor dysfunction
 Neurochemistry
 Neurotoxicity
 Nonhuman
 Priority journal
 Rat
 Stereotypy
 Animals
 Behavior, Animal
 Brain
 Dopamine
 Dose-Response Relationship, Drug
 Herbicides
 Injections, Intraperitoneal
 Injections, Subcutaneous
 Male
 Motor Activity
 Norepinephrine
 Paraquat
 Rats
 Rats, Wistar
 Valine

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URI

https://hdl.handle.net/20.500.14740/6411

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Scopus: Year 1983-2021

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