Publication: Incidence Rate and Associated Factors of Early Onset Sepsis Among Neonate Born at ≥35 Weeks’ Gestation in Thai Tertiary Hospital
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Issued Date
2023-01-01
Resource Type
eISSN
11786973
Scopus ID
2-s2.0-85163843005
Journal Title
Infection and Drug Resistance
Volume
16
Start Page
4093
End Page
4100
Rights Holder(s)
SCOPUS
Bibliographic Citation
Infection and Drug Resistance Vol.16 (2023) , 4093-4100
Suggested Citation
Aeimcharnbanchong K. Incidence Rate and Associated Factors of Early Onset Sepsis Among Neonate Born at ≥35 Weeks’ Gestation in Thai Tertiary Hospital. Infection and Drug Resistance Vol.16 (2023) , 4093-4100. 4100. doi:10.2147/IDR.S415590 Retrieved from: https://hdl.handle.net/20.500.14740/20372
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Abstract
Purpose: This study aimed to find the incidence rate and associated factors of EOS in neonates with 35 weeks of gestational age or more at Panyananthaphikkhu Chonprathan Medical Center (PCMC) in order to develop effective prevention and treatment strategies to reduce neonatal mortality. Methods: A cross-sectional study was done in a single-center neonatal intensive care unit at PCMC. Data were collected from October 2016 to September 2021 from all neonates with 35 weeks of gestational age or more with EOS and randomly collected from neonates with 35 weeks of gestational age or more without EOS. The associated factors of EOS were shown as an odds ratio by multivariate analysis of binary logistic regression. Results: In this study, 595 neonates were enrolled and divided into 2 groups – EOS group (193 neonates) and non-EOS group (402 neonates). The incidence rate of EOS was 21.23/1000 live births, comprising 2 culture-positive EOS neonates (0.22/1000 live births) and 191 culture-negative EOS neonates (21/1000 live births). The common clinical manifestations in the EOS group were respiratory distress (157 neonates, 81%), temperature instability (43 neonates, 22.3%) and poor feeding (39 neonates, 20.2%). Statistically significant relationship (p-value < 0.05) was found in prolonged rupture of membrane (OR 11.7, 95% CI: 2.54–53.88), low birth weight (OR 2.3, 95% CI: 1.25–4.4) and normal Apgar score at 5 minutes after birth (OR 0.5, 95% CI: 0.31–0.71). Conclusion: Our study shows that the incidence rate of culture positive EOS in late preterm and term is very low. EOS was significantly associated with prolonged rupture of membrane and low birth weight whereas lower rate of EOS was significantly associated with normal Apgar score at 5 minutes after birth. Efforts to recognize these factors early and effectively resuscitate neonates may reduce and prevent neonatal morbidity and mortality.