Publication: Clinical features and antibiotic susceptibility of salmonella gastroenteritis in children: A ten-year review
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Issued Date
2020
Resource Type
File Type
application/pdf
ISSN
3005283
Other identifier(s)
2-s2.0-85096398102
Rights
Srinakharinwirot University
Rights Holder(s)
Scopus
Bibliographic Citation
Medical Journal of Malaysia. Vol 75, No.6 (2020), p.672-676
Suggested Citation
Takkinsatian P., Silpskulsuk C., Prommalikit O. Clinical features and antibiotic susceptibility of salmonella gastroenteritis in children: A ten-year review. Medical Journal of Malaysia. Vol 75, No.6 (2020), p.672-676. Retrieved from: https://hdl.handle.net/20.500.14740/5842
Author(s)
Abstract
Introduction: Salmonella is a common organism, causing intestinal and extraintestinal infections among Thai children, especially infants, and leading to overwhelming antibiotic use. Materials and Methods: In this retrospective review, data collected during 2006-2015 from the medical charts of patients with evidence of infection, caused by any Salmonella serogroup or clinical form, were examined. We aimed to assess the clinical manifestations, antibiotic susceptibility, and antibiotic use in children with Salmonella gastroenteritis over the ten years’ period. Results: A total of 419 patients had non-typhoidal Salmonella infection. Four-hundred (95.5%) patients were diagnosed with acute gastroenteritis, which was common in children aged <12 months (72.3%). The clinical features of patients with gastroenteritis included fever (74.5%), diarrhoea with bloody mucus (60.5%), watery diarrhoea (39.5%), and vomiting (19.8%). Serogroup B was most commonly detected in the stool specimens. The susceptibility of non-typhoidal Salmonella to ampicillin, norfloxacin, and co-trimoxazole was 36.3%, 98.0%, and 80.5%, respectively. Serogroup B was the most resistant strain, which was sensitive to ampicillin in only 21.6% of specimens, while it showed high susceptibility to norfloxacin and co-trimoxazole (98.1 and 84.0%, respectively). Third-generation cephalosporin and fluoroquinolone were most commonly prescribed. Conclusions: Acute gastroenteritis is the most common form of Salmonella infection. Gastroenteritis caused by serogroup B is still the most common infection, which mostly occurs among infants under one year of age. The majority of stool specimens were still susceptible to antimicrobial agents, especially fluoroquinolone and cotrimoxazole; however, there was an overuse of antibiotics without proper indications. © 2020, Malaysian Medical Association. All rights reserved.
Subject(s)
Ampicillin
Cephalosporin
Cotrimoxazole
Norfloxacin
Quinoline derived antiinfective agent
Adolescent
Antibiotic sensitivity
Article
Bacteremia
Bacterial arthritis
Bloody mucus
Child
Child hospitalization
Clinical feature
Diarrhea
Female
Fever
Gastroenteritis
Human
Immunocompromised patient
Infant
Intensive care unit
Length of stay
Major clinical study
Male
Meningitis
Newborn
Retrospective study
Salmonella
Serotype
Verner Morrison syndrome
Vomiting
Cephalosporin
Cotrimoxazole
Norfloxacin
Quinoline derived antiinfective agent
Adolescent
Antibiotic sensitivity
Article
Bacteremia
Bacterial arthritis
Bloody mucus
Child
Child hospitalization
Clinical feature
Diarrhea
Female
Fever
Gastroenteritis
Human
Immunocompromised patient
Infant
Intensive care unit
Length of stay
Major clinical study
Male
Meningitis
Newborn
Retrospective study
Salmonella
Serotype
Verner Morrison syndrome
Vomiting