Publication:
Study of genotoxic effects of antidiarrheal medicinal herbs on human cells in vitro.

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Issued Date

1995

Resource Type

Article

File Type

application/pdf

ISSN

1251562

Other identifier(s)

2-s2.0-0029442359

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

The Southeast Asian journal of tropical medicine and public health. Vol 26 Suppl 1, (1995), p.306-310

Suggested Citation

Settheetham W., Ishida T. Study of genotoxic effects of antidiarrheal medicinal herbs on human cells in vitro.. The Southeast Asian journal of tropical medicine and public health. Vol 26 Suppl 1, (1995), p.306-310. Retrieved from: https://hdl.handle.net/20.500.14740/7412

Title

Study of genotoxic effects of antidiarrheal medicinal herbs on human cells in vitro.

Author(s)

Settheetham W.
 Ishida T.

Abstract

The use of medicinal herbs has been a common practice in Asia but their genotoxic properties are little known. In the present study, genotoxic effects of three antidiarrheal herbs, guava leaf, mangosteen peel and pomegranate peel, were examined using established human cell lines, Raji and P3HR-1. Cells were treated with boiled-water extract of the herbs at various concentrations for 24 and 48 hours in vitro. Cell growth and viability were dose dependently reduced. No apparent chromosomal aberrations were induced by the treatment. Administration of pomegranate extract induced apoptotic DNA fragmentation. This genotoxicity test system is simple and convenient for the primary screening.

Subject(s)

Antidiarrheal agent
 DNA
 Mutagenic agent
 Plant extract
 Angiosperm
 Article
 Burkitt lymphoma
 Cell culture
 Cell division
 Cell line
 Cell survival
 Chinese medicine
 Chromosome aberration
 Comparative study
 Drug effect
 Fruit
 Human
 Medicinal plant
 Mutagen testing
 Phytotherapy
 Angiosperms
 Antidiarrheals
 Burkitt Lymphoma
 Cell Division
 Cell Line
 Cell Survival
 Chromosome Aberrations
 DNA, Neoplasm
 Fruit
 Humans
 Medicine, Chinese Traditional
 Mutagenicity Tests
 Mutagens
 Phytotherapy
 Plant Extracts
 Plants, Medicinal
 Tumor Cells, Cultured

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URI

https://hdl.handle.net/20.500.14740/7412

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Scopus: Year 1983-2021

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