Publication:
Thermal, mechanical and drug release characteristics of an acrylic film using active pharmaceutical ingredient as non-traditional plasticizer

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Issued Date

2016

Resource Type

Article

File Type

application/pdf

ISSN

3639045

DOI

10.3109/03639045.2015.1062513

Other identifier(s)

2-s2.0-84964330168

Rights Holder(s)

Scopus

Bibliographic Citation

Drug Development and Industrial Pharmacy. Vol 42, No.4 (2016), p.644-653

Suggested Citation

Wiranidchapong C., Kieongarm W., Managit C., Phrompittayarat W. Thermal, mechanical and drug release characteristics of an acrylic film using active pharmaceutical ingredient as non-traditional plasticizer. Drug Development and Industrial Pharmacy. Vol 42, No.4 (2016), p.644-653. doi:10.3109/03639045.2015.1062513 Retrieved from: https://hdl.handle.net/20.500.14740/5959

Title

Thermal, mechanical and drug release characteristics of an acrylic film using active pharmaceutical ingredient as non-traditional plasticizer

Author(s)

Wiranidchapong C.
 Kieongarm W.
 Managit C.
 Phrompittayarat W.

Abstract

The objective of this study was to investigate thermal and mechanical properties as well as in vitro drug release of Eudragit® RL (ERL) film using chlorpheniramine maleate (CPM) as either active pharmaceutical ingredient or non-traditional plasticizer. Differential scanning calorimeter was used to measure the glass transition temperature (Tg) of 0-100% w/w CPM in ERL physical mixture. Instron testing machine was used to investigate Young's modulus, tensile stress and tensile strain (%) of ERL film containing 20-60% w/w CPM. Finally, a Franz diffusion cell was used to study drug release from ERL films obtained from four formulations, i.e. CRHP0/0, CRHP0/5, CRHP2/0 and CRHP2/5. The Tg of ERL was decreased when the weight percentage of CPM increased. The reduction of the Tg could be described by Kwei equation, indicating the interaction between CPM and ERL. Modulus and tensile stress decreased whereas tensile strain (%) increased when weight percentage of CPM increased. The change of mechanical properties was associated with the reduction of the Tg when weight percentage of CPM increased. ERL films obtained from four formulations could release the drug in no less than 10 h. Cumulative amount of drug release per unit area of ERL film containing only CPM (CRHP0/0) was lower than those obtained from the formulations containing traditional plasticizer (CRHP0/5), surfactant (CRHP2/0) or both of them (CRHP2/5). The increase of drug release was a result of the increase of drug permeability through ERL film and drug solubility based on traditional plasticizer and surfactant, respectively. © 2015 Taylor & Francis.

Subject(s)

Chlorpheniramine maleate
 Eudragit
 Polyacrylic acid
 Surfactant
 Eudragit
 Plasticizer
 Polymer
 Article
 Differential scanning calorimetry
 Drug diffusion
 Drug formulation
 Drug penetration
 Drug release
 Drug solubility
 Glass transition temperature
 In vitro study
 Investigative procedures
 Stress
 Tensile stress
 Young modulus
 Biomechanics
 Chemistry
 Medicinal chemistry
 Metabolism
 Tensile strength
 X ray diffraction
 Biomechanical Phenomena
 Chemistry, Pharmaceutical
 Drug Liberation
 Plasticizers
 Polymers
 Tensile Strength
 X-Ray Diffraction

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URI

https://hdl.handle.net/20.500.14740/5959

Collections

Scopus: Year 1983-2021

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