Publication:
Salivary and serum interleukin-17A and interleukin-18 levels in patients with type 2 diabetes mellitus with and without periodontitis

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Issued Date

2020

Resource Type

Article

File Type

application/pdf

ISSN

19326203

DOI

10.1371/journal.pone.0228921

Other identifier(s)

2-s2.0-85079335321

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

PLoS ONE. Vol 15, No.2 (2020)

Suggested Citation

Techatanawat S., Surarit R., Chairatvit K., Khovidhunkit W., Roytrakul S., Thanakun S., Kobayashi H., Khovidhunkit S.-O.P., Izumi Y. Salivary and serum interleukin-17A and interleukin-18 levels in patients with type 2 diabetes mellitus with and without periodontitis. PLoS ONE. Vol 15, No.2 (2020). doi:10.1371/journal.pone.0228921 Retrieved from: https://hdl.handle.net/20.500.14740/4673

Title

Salivary and serum interleukin-17A and interleukin-18 levels in patients with type 2 diabetes mellitus with and without periodontitis

Author(s)

Techatanawat S.
 Surarit R.
 Chairatvit K.
 Khovidhunkit W.
 Roytrakul S.
 Thanakun S.
 Kobayashi H.
 Khovidhunkit S.-O.P.
 Izumi Y.

Abstract

Objective Interleukin (IL)-17A and IL-18 have been proposed to play important roles in periodontitis and type 2 diabetes mellitus (DM), but human data are conflicting. The present study aimed to investigate the roles of IL-17A and IL-18 in periodontitis and DM by measuring salivary and serum levels, respectively. Materials and methods A total of 49 participants with type 2 DM and 25 control subjects without type 2 DM were recruited. A periodontal screening and recording (PSR) index (0, 1-2, 3, and 4) was used to classify whether these subjects had periodontitis. Salivary and serum IL-17A and IL-18 levels were measured by enzyme-linked immunosorbent assay. Multiple linear regression analyses were used to evaluate the associations between these cytokines and clinical parameters. Results Salivary IL-17A levels were not significantly different between patients with DM and controls, however, the levels were significantly higher in controls with periodontitis than those without periodontitis (p = 0.031). Salivary IL-17A levels were significantly associated with the PSR index (β = 0.369, p = 0.011). Multiple linear regression analyses revealed the association of salivary IL-18 levels and fasting plasma glucose (β = 0.270, p = 0.022) whereas serum IL-18 levels were associated with HbA1C (β = 0.293, p = 0.017). No correlation between salivary and serum levels of IL-17A and IL-18 was found. Conclusion Salivary IL-17A was strongly associated with periodontitis, whereas salivary IL-18 was associated with FPG and serum IL-18 was associated with HbA1C. These results suggest the role of these cytokines in periodontal inflammation and DM. index (β = 0.369, p = 0.011). Multiple linear regression analyses revealed the association of salivary IL-18 levels and fasting plasma glucose (β = 0.270, p = 0.022) whereas serum IL-18 levels were associated with HbA1C (β = 0.293, p = 0.017). No correlation between salivary and serum levels of IL-17A and IL-18 was found. Conclusion Salivary IL-17A was strongly associated with periodontitis, whereas salivary IL-18 was associated with FPG and serum IL-18 was associated with HbA1C. These results suggest the role of these cytokines in periodontal inflammation and DM. © 2020 Techatanawat et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Subject(s)

Glucose
 Hemoglobin A1c
 Interleukin 17
 Interleukin 18
 Cytokine
 Glycosylated hemoglobin
 Hemoglobin A1c protein, human
 IL17A protein, human
 Interleukin 17
 Interleukin 18
 Interleukin 18 protein, human
 Adult
 Article
 Clinical article
 Controlled study
 Demography
 Disease association
 Enzyme linked immunosorbent assay
 Estimated glomerular filtration rate
 Female
 Glucose blood level
 Human
 Male
 Non insulin dependent diabetes mellitus
 Pathogenesis
 Periodontal disease assessment
 Periodontal screening and recording index
 Periodontitis
 Population research
 Protein blood level
 Protein saliva level
 Saliva level
 Blood
 Case control study
 Chemistry
 Chronic periodontitis
 Complication
 Gingivitis
 Immunology
 Metabolism
 Middle aged
 Non insulin dependent diabetes mellitus
 Periodontal index
 Periodontitis
 Saliva
 Adult
 Case-Control Studies
 Chronic Periodontitis
 Cytokines
 Diabetes Mellitus, Type 2
 Female
 Gingival Crevicular Fluid
 Glycated Hemoglobin A
 Humans
 Interleukin-17
 Interleukin-18
 Male
 Middle Aged
 Periodontal Index
 Periodontitis
 Saliva

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URI

https://hdl.handle.net/20.500.14740/4673

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Scopus: Year 1983-2021

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