Publication: Risk factors and prognosis of spontaneously ruptured hepatocellular carcinoma in Thailand
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Issued Date
2018
Resource Type
File Type
application/pdf
ISSN
15137368
Other identifier(s)
2-s2.0-85058922432
Rights Holder(s)
Scopus
Bibliographic Citation
Asian Pacific Journal of Cancer Prevention. Vol 19, No.12 (2018), p.3629-3634
Suggested Citation
Kerdsuknirun J., Vilaichone V., Vilaichone R.-K. Risk factors and prognosis of spontaneously ruptured hepatocellular carcinoma in Thailand. Asian Pacific Journal of Cancer Prevention. Vol 19, No.12 (2018), p.3629-3634. doi:10.31557/APJCP.2018.19.12.3629 Retrieved from: https://hdl.handle.net/20.500.14740/5777
Author(s)
Abstract
Objective: Hepatocellular carcinoma (HCC) is the fatal cancer worldwide. Spontaneously Rupture remains important complication of HCC. The incidence of spontaneous HCC rupture was high in ASEAN but limited studies were reported. The aim of this study was to evaluate predictors and overall survival of ruptured HCC in tertiary care center in Thailand. Methods: We conducted a retrospective cohort study of HCC patients aged ≥ 15 years old during January 2012-January 2016 and followed up through June 2016 at Thammasat University Hospital, Thailand. All clinical information, laboratory and radiologic findings were collected from reviewing computer data base of medical records. Results: 333 patients had completely retrievable information. Of which, 51patients (15.3%) had spontaneous ruptured HCC. Clinical symptoms with abdominal discomfort and anemic symptoms were significantly higher in ruptured than non-ruptured HCC groups. (76.47% vs.39.36%: p < 0.001, 13.73vs.0.71%, p < 0.001). Furthermore, size of tumors, presences of metastasis and serum AFP > 200 ng/mL were significantly higher in ruptured than non-ruptured HCC groups (10.29cm. vs. 6.47cm. p < 0.001, 17.65% vs. 8.16%, p=0.034, 60.78% vs. 36.88%, p=0.001, respectively). In multivariate analysis, age, abdominal discomfort, anemic symptoms, Child-Pugh score > 6 were independent risk factors of HCC rupture (OR=0.96, 95%CI=0.93-0.99, p=0.02; OR=3.47, 95%CI=1.26-9.6, p=0.016; OR=54.51, 95%CI=7.09-418.89, p < 0.001; OR=2.62, 95%CI=1.09-6.31, p=0.031, respectively). 1-year and 2-year survival rates of ruptured HCC were 66.9% and 44.6% respectively. Conclusions: Age, abdominal discomfort, anemic symptoms and Child-Pugh score > 6 might be predictive factors of spontaneous ruptured HCC. Ruptures of HCC remained a fatal disease with poor survival rate in Thailand. Appropriate treatment in early stage could be effective tool to improve the treatment outcomes. © 2018, Asian Pacific Organization for Cancer Prevention.
Subject(s)
Aged
Female
Human
Liver cell carcinoma
Liver tumor
Male
Pathology
Prognosis
Retrospective study
Risk factor
Rupture
Survival rate
Thailand
Treatment outcome
Aged
Carcinoma, Hepatocellular
Female
Humans
Liver Neoplasms
Male
Prognosis
Retrospective Studies
Risk Factors
Rupture, Spontaneous
Survival Rate
Thailand
Treatment Outcome
Female
Human
Liver cell carcinoma
Liver tumor
Male
Pathology
Prognosis
Retrospective study
Risk factor
Rupture
Survival rate
Thailand
Treatment outcome
Aged
Carcinoma, Hepatocellular
Female
Humans
Liver Neoplasms
Male
Prognosis
Retrospective Studies
Risk Factors
Rupture, Spontaneous
Survival Rate
Thailand
Treatment Outcome