Publication: Acute monoblastic leukemia with t(10;11)(p12;q23) presenting with pulmonary involvement: A case report and literature review
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Issued Date
2008
Resource Type
File Type
application/pdf
ISSN
1252208
Other identifier(s)
2-s2.0-44249109745
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol 91, No.4 (2008), p.559-563
Suggested Citation
Prayongratana K., Kulpraneet M., Panichchob P., Tantisiriwat W. Acute monoblastic leukemia with t(10;11)(p12;q23) presenting with pulmonary involvement: A case report and literature review. Journal of the Medical Association of Thailand. Vol 91, No.4 (2008), p.559-563. Retrieved from: https://hdl.handle.net/20.500.14740/4077
Abstract
A forty-three-year-old Thai man presented with acute fever and dyspnea for one week with bilateral patchy infiltration, pancytopenia with monoblast. Bone marrow study was consistent with acute monoblastic leukemia. Lung lesions rapidly progressed to acute respiratory failure, which required intubation. Bronchoscopy with bronchoalveolar lavage revealed monotonous monoblast infiltration. Induction chemotherapy with 7 + 3 regimen was administered to halt the progression of leukemic pulmonary infiltration. Although there was clinical improvement, the chest radiograph developed crescent formation in the right upper lung field. Invasive pulmonary aspergillosis was suspected and successfully treated with antifungal agent. After peripheral blood recovery, bone marrow evaluation was performed and complete remission was established. HLA matching was sent to prepare for hematopoietic stem cell transplantation (HSCT). The literature review showed that the appropriate treatment for the patients with t(10;11)(p12;q23) was HSCT, but there was no data concerning correlation of t(10;11)(p12;q23) and pulmonary infiltration. This may be due to the low incidence of leukemic infiltration of acute leukemia patients, which is 0.48% and 3.06% in acute myeloid leukemia and acute monoblastic leukemia, respectively.
Subject(s)
Caspofungin
Cytarabine
Idarubicin
Voriconazole
Acute disease
Acute granulocytic leukemia
Acute lymphoblastic leukemia
Acute monocytic leukemia
Acute respiratory failure
Adult
Article
Bleeding
Bone marrow examination
Bronchoscopy
Cancer chemotherapy
Cancer regression
Case report
Cell infiltration
Continuous infusion
Cytogenetics
Disease course
Dyspnea
Fever
Hematopoietic stem cell transplantation
Human
Incidence
Intubation
Laboratory test
Lung aspergillosis
Lung infiltrate
Lung lavage
Lung lesion
Male
Pancytopenia
Thorax radiography
Treatment outcome
Adult
Antibiotics, Antineoplastic
Antifungal Agents
Antimetabolites, Antineoplastic
Aspergillosis, Allergic Bronchopulmonary
Bronchoalveolar Lavage
Cytarabine
Echinocandins
Hematopoietic Stem Cell Transplantation
Humans
Idarubicin
Leukemia, Monocytic, Acute
Lung Neoplasms
Male
Pyrimidines
Thailand
Triazoles
Cytarabine
Idarubicin
Voriconazole
Acute disease
Acute granulocytic leukemia
Acute lymphoblastic leukemia
Acute monocytic leukemia
Acute respiratory failure
Adult
Article
Bleeding
Bone marrow examination
Bronchoscopy
Cancer chemotherapy
Cancer regression
Case report
Cell infiltration
Continuous infusion
Cytogenetics
Disease course
Dyspnea
Fever
Hematopoietic stem cell transplantation
Human
Incidence
Intubation
Laboratory test
Lung aspergillosis
Lung infiltrate
Lung lavage
Lung lesion
Male
Pancytopenia
Thorax radiography
Treatment outcome
Adult
Antibiotics, Antineoplastic
Antifungal Agents
Antimetabolites, Antineoplastic
Aspergillosis, Allergic Bronchopulmonary
Bronchoalveolar Lavage
Cytarabine
Echinocandins
Hematopoietic Stem Cell Transplantation
Humans
Idarubicin
Leukemia, Monocytic, Acute
Lung Neoplasms
Male
Pyrimidines
Thailand
Triazoles