Publication: Non-pharmacologic interventions for management of radiation-induced dry mouth: A systematic review
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Issued Date
2024-07-01
Resource Type
ISSN
1354523X
eISSN
16010825
Scopus ID
2-s2.0-85176753348
Pubmed ID
37946598
Journal Title
Oral Diseases
Volume
30
Issue
5
Start Page
2876
End Page
2893
Rights Holder(s)
SCOPUS
Bibliographic Citation
Oral Diseases Vol.30 No.5 (2024) , 2876-2893
Suggested Citation
Khamdi S., Matangkasombut O., Lam-Ubol A. Non-pharmacologic interventions for management of radiation-induced dry mouth: A systematic review. Oral Diseases Vol.30 No.5 (2024) , 2876-2893. 2893. doi:10.1111/odi.14804 Retrieved from: https://hdl.handle.net/20.500.14740/20118
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Abstract
Objectives: Radiation-induced dry mouth negatively impacts patients' oral health and quality of life. Currently, evidence-based recommendation for non-pharmacologic interventions is still lacking. This study aimed to systematically review clinical trials evaluating the efficacy of non-pharmacologic interventions in cancer patients with radiation-induced dry mouth. Methods: Randomized controlled trials from 2000 were searched from 4 databases, including MEDLINE, Cochrane, Embase via OVID, and SCOPUS, up to December 16th, 2022 (PROSPERO registration CRD42022378405). The risk of bias was assessed using the revised Cochrane risk of bias assessment tool. Results: Twenty-one studies were included: 11 on artificial saliva, 4 on electrical nerve stimulation (TENS), 2 on acupuncture, and one study each on low-level laser therapy, stem cells, chewing gum, and probiotics. Overall bias was low, medium, and high in 33%, 48%, and 19% of the studies, respectively. Certain artificial saliva products and TENS were shown to improve dry mouth symptoms and salivary flow rate (SFR). One study showed that stem cell transplantation significantly increased SFR. Conclusions: The evidence suggested that certain artificial saliva products and TENS are promising management. However, the evidence was still limited due to heterogeneity of interventions and outcome measurements. Thus, future studies using standard measurements and long-term follow-up are warranted.