Publication:
Enantioseparation of (S)-amlodipine from pharmaceutical wastewater by hollow-fiber supported liquid membrane: Central composite design and optimization

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Issued Date

2017

Resource Type

Article

File Type

application/pdf

ISSN

19443994

DOI

10.5004/dwt.2017.20191

Other identifier(s)

2-s2.0-85020268513

Rights Holder(s)

Scopus

Bibliographic Citation

Desalination and Water Treatment. Vol 72, (2017), p.207-215

Suggested Citation

Sunsandee N., Kunthakudee N., Chutvirasakul B., Phatanasri S., Ramakul P. Enantioseparation of (S)-amlodipine from pharmaceutical wastewater by hollow-fiber supported liquid membrane: Central composite design and optimization. Desalination and Water Treatment. Vol 72, (2017), p.207-215. doi:10.5004/dwt.2017.20191 Retrieved from: https://hdl.handle.net/20.500.14740/4203

Title

Enantioseparation of (S)-amlodipine from pharmaceutical wastewater by hollow-fiber supported liquid membrane: Central composite design and optimization

Author(s)

Sunsandee N.
 Kunthakudee N.
 Chutvirasakul B.
 Phatanasri S.
 Ramakul P.

Abstract

The enantioseparation of (S)-amlodipine and (R)-amlodipine from pharmaceutical wastewater by hollow fiber supported liquid membrane was examined. The pH effects of feed solution, concentration of (+)-DBTA, temperature and the flow rates of feed and stripping solution were investigated. A central composite design (CCD) was used for the design of experiment and to determine the significant factors and their interactions. Regression equations were created from the CCD to predict the percentages of extraction and stripping with varying factor levels. The validity of the model was evaluated, and the optimized condition determined by response surface methodology. The highest extraction and stripping performances were 82.0 and 76.0%, respectively. © 2017, Desalination Publications. All rights reserved.

Subject(s)

Concentration (composition)
 Drug
 Extraction method
 Membrane
 Response surface methodology
 Separation
 Solution
 Wastewater treatment

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URI

https://hdl.handle.net/20.500.14740/4203

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Scopus: Year 1983-2021

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