Publication:
Associations of left ventricular systolic dysfunction with the factors among Thai patients on peritoneal dialysis: A cross-sectional study

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Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

14712369

DOI

10.1186/s12882-019-1418-7

Other identifier(s)

2-s2.0-85069000131

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

BMC Nephrology. Vol 20, No.1 (2019)

Suggested Citation

Angkananard T., Janma J., Wannasiri T., Sangthong P., Changsirikulchai S. Associations of left ventricular systolic dysfunction with the factors among Thai patients on peritoneal dialysis: A cross-sectional study. BMC Nephrology. Vol 20, No.1 (2019). doi:10.1186/s12882-019-1418-7 Retrieved from: https://hdl.handle.net/20.500.14740/5207

Title

Associations of left ventricular systolic dysfunction with the factors among Thai patients on peritoneal dialysis: A cross-sectional study

Author(s)

Angkananard T.
 Janma J.
 Wannasiri T.
 Sangthong P.
 Changsirikulchai S.

Abstract

Background: Factors associated with left ventricular systolic dysfunction (LVSD) of peritoneal dialysis (PD) patients are limited. We aim to explore and quantify the associated factors of LVSD among PD patients. Methods: Participants from a PD clinic treated between 2012 and 2014 at the HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Nakhon Nayok, Thailand were recruited and divided into 2 groups according to their left ventricular ejection fraction (LVEF) (< 50% vs. ≥ 50%) with LVEF < 50% considered as LVSD. Correlations among the clinical, laboratory and echocardiographic variables were analyzed. The factors associated with LVSD were explored with univariate and multivariate logistic regression analyses. Beta coefficient along with odds ratio and 95% confidence interval (CI) were calculated and the P value < 0.05 was considered significant. Results: Among 103 subjects stratified as LVSD (n = 18, 17.5%). The mean (SD) age was 59.3 (12.7) years, and nearly halves were males. Preexisting CAD, diabetes (DM) and current smoking were 20 (19.4%), 63 (61.2%) and 23 (22.3%) patients, respectively. The median time of dialysis vintage was 12 (3, 24) months. Factors associated with LVSD and corresponding ORs with 95% CI by multivariate analysis were prior coronary artery disease (CAD) [5.08 (1.16, 22.19)], DM [6.36 (1.29, 31.49)], smoking [10.62 (2.17, 51.99)], neutrophil to lymphocyte ratio (NLR) > 3.6 [6.77 (1.41, 32.52)], and high serum phosphate [9.39 (2.16, 40.92)] were significantly associated with LVSD. Conclusions: Prior history of CAD, DM, smoking, high NLR and serum phosphate levels were found to be associated with LVSD for our PD patients. The evidence from prospective study is needed to confirm the predictive value of these variables. © 2019 The Author(s).

Subject(s)

Phosphate
 Adult
 Article
 Coronary artery disease
 Correlational study
 Cross-sectional study
 Diabetes mellitus
 Disease association
 Echocardiography
 Female
 Heart left ventricle ejection fraction
 Human
 Human cell
 Laboratory test
 Left ventricular systolic dysfunction
 Major clinical study
 Male
 Medical history
 Middle aged
 Neutrophil lymphocyte ratio
 Peritoneal dialysis
 Phosphate blood level
 Sex ratio
 Smoking
 Thai (people)
 University hospital
 Aged
 Chronic kidney failure
 Complication
 Epidemiology
 Heart left ventricle function
 Risk factor
 Systole
 Thailand
 Aged
 Cross-Sectional Studies
 Female
 Humans
 Kidney Failure, Chronic
 Male
 Middle Aged
 Peritoneal Dialysis
 Risk Factors
 Systole
 Thailand
 Ventricular Dysfunction, Left

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URI

https://hdl.handle.net/20.500.14740/5207

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Scopus: Year 1983-2021

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