Publication:
Effects of Pueraria mirifica, an herb containing phytoestrogens, on reproductive organs and fertility of adult male mice

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Issued Date

2006

Resource Type

Article

File Type

application/pdf

ISSN

1355008X

DOI

10.1385/ENDO:30:1:93

Other identifier(s)

2-s2.0-33845870129

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Endocrine. Vol 30, No.1 (2006), p.93-101

Suggested Citation

Jaroenporn S., Malaivijitnond S., Wattanasirmkit K., Trisomboon H., Watanabe G., Taya K., Cherdshewasart W. Effects of Pueraria mirifica, an herb containing phytoestrogens, on reproductive organs and fertility of adult male mice. Endocrine. Vol 30, No.1 (2006), p.93-101. doi:10.1385/ENDO:30:1:93 Retrieved from: https://hdl.handle.net/20.500.14740/5571

Title

Effects of Pueraria mirifica, an herb containing phytoestrogens, on reproductive organs and fertility of adult male mice

Author(s)

Jaroenporn S.
 Malaivijitnond S.
 Wattanasirmkit K.
 Trisomboon H.
 Watanabe G.
 Taya K.
 Cherdshewasart W.

Abstract

The effects of Pueraria mirifica (PM) on reproductive organs and fertility of adult male mice were investigated. Male mice were divided into four groups (10 mice/group). Groups 1-3 were orally treated with PM at doses of 0 (PM-0), 10 (PM-10), and 100 (PM-100) mg/kg BW/d in 0.2 mL distilled water, and group 4 was subcutaneously injected with 200 μg/kg BW/d of synthetic estrogen diesthylstilbestol (DES). The treatment schedule was separated into two periods: treatment and posttreatment (8 wk for each period). The PM-10 and PM-100 treatments had no effect on testicular weight, sperm number, and serum LH, FSH, and testosterone levels. Only the PM-100 treatment reduced weights of epididymes and seminal vesicle and the sperm motility and viability. Histopathological examination demonstrated that testis, epididymis, and seminal vesicle were normal in all doses of PM treatment. PM-treated males showed no alterations in mating efficiency and on causing pregnancy of their female partners. DES injection impaired all those parameters. Offspring fathered by the PM- and DES-treated males exhibited neither malformations nor change of body weight gains, and the reproductive organ weights of 50-d old pups were in the normal range. The present data clearly demonstrate that a long-term treatment of PM at doses 10 and 100 mg/kg BW/d, via oral route, does not alter a male fertility and a hypothalamus- pituitary-testis axis. Although PM-100 can cause some moderate impairment, no persistent effects were observed. Most of PM-treated mice increased the mating efficiency after stop treatment. © 2006 by Humana Press Inc. All rights of any nature whatsoever reserved.

Subject(s)

Diethylstilbestrol
 Follitropin
 Herbaceous agent
 Luteinizing hormone
 Phytoestrogen
 Testosterone
 Water
 Animal experiment
 Animal tissue
 Article
 Controlled study
 Drug effect
 Epididymis
 Female
 Genital system
 Histopathology
 Hypophysis testis system
 Hypothalamus hypophysis system
 Long term care
 Luteinizing hormone blood level
 Male
 Male fertility
 Mating
 Mouse
 Nonhuman
 Organ weight
 Pregnancy
 Priority journal
 Progeny
 Pueraria
 Pueraria mirifica
 Seminal vesicle
 Sexual behavior
 Spermatozoon count
 Spermatozoon motility
 Testis
 Testis weight
 Testosterone blood level
 Animals
 Diethylstilbestrol
 Epididymis
 Female
 Fertility
 Follicle Stimulating Hormone
 Genitalia, Male
 Histocytochemistry
 Luteinizing Hormone
 Male
 Mice
 Organ Size
 Phytoestrogens
 Pregnancy
 Pueraria
 Seminal Vesicles
 Sperm Count
 Sperm Motility
 Testis
 Testosterone

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URI

https://hdl.handle.net/20.500.14740/5571

Collections

Scopus: Year 1983-2021

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