Publication:
Hypoxylonone, a new oxa-bridged seven-membered ring analog from fungus Hypoxylon cf. subgilvum SWUF15-004

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Issued Date

2022

Resource Type

Article

Language

eng

File Type

application/pdf

ISSN

14786419

DOI

10.1080/14786419.2022.2125968

Rights Holder(s)

Scopus

Bibliographic Citation

Kasetsart Journal of Social Sciences. Vol 43, No.4 (2022), p.1085-1094

Suggested Citation

Jantaharn P., Mongkolthanaruk W., Suwannasai N., Senawong T., Boonmak J., Youngme S., Mccloskey S. Hypoxylonone, a new oxa-bridged seven-membered ring analog from fungus Hypoxylon cf. subgilvum SWUF15-004. Kasetsart Journal of Social Sciences. Vol 43, No.4 (2022), p.1085-1094. doi:10.1080/14786419.2022.2125968 Retrieved from: https://hdl.handle.net/20.500.14740/9332

Title

Hypoxylonone, a new oxa-bridged seven-membered ring analog from fungus Hypoxylon cf. subgilvum SWUF15-004

Author(s)

Jantaharn P.
 Mongkolthanaruk W.
 Suwannasai N.
 Senawong T.
 Boonmak J.
 Youngme S.
 Mccloskey S.

Abstract

A new oxa-bridged seven-membered ring analog, hypoxylonone (1), and thirteen known compounds (2–14) were isolated from fungus Hypoxylon cf. subgilvum SWUF15-004. The structures were elucidated by the analysis of spectroscopic (IR, 1 D and 2 D NMR), HRESIMS and X-ray diffraction (MoKα) data. Several isolated compounds were evaluated for cytotoxicity against four human cancer cell lines (HeLa, HT29, MCF-7, A549). Compound 1 exhibited weak inhibitory effects of the nitric oxide production in RAW264.7 cells. Compounds 8 and 9 exhibited slight cytotoxicity. © 2022 Informa UK Limited, trading as Taylor & Francis Group.

Subject(s)

8-oxabicyclo[3.2.1]octane
 Cytotoxicity
 Hypoxylon cf. subgilvum
 Oxa-bridged seven-membered ring

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URI

https://hdl.handle.net/20.500.14740/9332

Collections

Scopus: Year 2022

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