Publication:
Impact of Neoadjuvant Chemoradiation on Short-Term Outcomes for Esophageal Squamous Cell Carcinoma Patients: A Meta-analysis

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Issued Date

2016

Resource Type

Article

File Type

application/pdf

ISSN

10689265

DOI

10.1245/s10434-016-5298-9

Other identifier(s)

2-s2.0-84976292383

Rights Holder(s)

Scopus

Bibliographic Citation

Annals of Surgical Oncology. Vol 23, No.11 (2016), p.3632-3640

Suggested Citation

Sathornviriyapong S., Matsuda A., Miyashita M., Matsumoto S., Sakurazawa N., Kawano Y., Yamada M., Uchida E. Impact of Neoadjuvant Chemoradiation on Short-Term Outcomes for Esophageal Squamous Cell Carcinoma Patients: A Meta-analysis. Annals of Surgical Oncology. Vol 23, No.11 (2016), p.3632-3640. doi:10.1245/s10434-016-5298-9 Retrieved from: https://hdl.handle.net/20.500.14740/5149

Title

Impact of Neoadjuvant Chemoradiation on Short-Term Outcomes for Esophageal Squamous Cell Carcinoma Patients: A Meta-analysis

Author(s)

Sathornviriyapong S.
 Matsuda A.
 Miyashita M.
 Matsumoto S.
 Sakurazawa N.
 Kawano Y.
 Yamada M.
 Uchida E.

Abstract

Background: Neoadjuvant chemoradiation (NCRT) has emerged as a component of the standard treatment for esophageal squamous cell carcinoma (SCC). The primary benefit of NCRT is an improvement in long-term survival; however, the impact of NCRT on short-term outcomes is unclear. Methods: A comprehensive electronic literature search was performed via the MEDLINE (PubMed), Cochrane Library, and Google Scholar databases through November 2015 for the inclusion of randomized controlled trials (RCTs) that evaluated short-term outcomes of patients administered NCRT followed by surgery compared with surgery alone for resectable esophageal SCC. The main outcome measures were postoperative mortality and morbidity. A meta-analysis was performed using random-effects models to calculate odds ratios (ORs) with 95 % confidence intervals (CIs). Results: Eight RCTs were included, for a total of 1058 patients. Meta-analysis of the overall postoperative mortality and cardiopulmonary complication rates showed that there was a significant increase for patients administered NCRT followed by surgery compared with surgery alone (OR 1.87, 95 % CI 1.07–3.28, p = 0.03, number of patients needed to harm = 33.3; and OR 2.12, 95 % CI 1.03–4.35, p = 0.04, respectively). Dropout before surgery was higher for patients in the NCRT followed by surgery group compared with patients in the surgery-alone group. NCRT has no statistically impact on anastomosis and other complications compared with surgery alone. Conclusions: NCRT for esophageal SCC significantly increases postoperative mortality and cardiopulmonary complications. © 2016, Society of Surgical Oncology.

Subject(s)

Adjuvant chemoradiotherapy
 Anastomosis
 Article
 Cancer patient
 Clinical decision making
 Esophageal squamous cell carcinoma
 Esophagus resection
 Heart disease
 Human
 Meta analysis
 Morbidity
 Outcome assessment
 Patient dropout
 Postoperative complication
 Randomized controlled trial (topic)
 Respiratory tract disease
 Surgical mortality
 Systematic review
 Adjuvant chemoradiotherapy
 Esophagus tumor
 Heart disease
 Lung disease
 Mortality
 Neoadjuvant therapy
 Postoperative complication
 Squamous cell carcinoma
 Survival rate
 Time factor
 Treatment outcome
 Carcinoma, Squamous Cell
 Chemoradiotherapy, Adjuvant
 Esophageal Neoplasms
 Esophagectomy
 Heart Diseases
 Humans
 Lung Diseases
 Neoadjuvant Therapy
 Patient Dropouts
 Postoperative Complications
 Randomized Controlled Trials as Topic
 Survival Rate
 Time Factors
 Treatment Outcome

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URI

https://hdl.handle.net/20.500.14740/5149

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Scopus: Year 1983-2021

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