Publication:
Roles of pyridine and pyrimidine derivatives as privileged scaffolds in anticancer agents

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Issued Date

2017

Resource Type

Review

File Type

application/pdf

ISSN

13895575

DOI

10.2174/1389557516666160923125801

Other identifier(s)

2-s2.0-85025119431

Rights Holder(s)

Scopus

Bibliographic Citation

Mini-Reviews in Medicinal Chemistry. Vol 17, No.10 (2017), p.869-901

Suggested Citation

Prachayasittikul S., Pingaew R., Worachartcheewan A., Sinthupoom N., Prachayasittikul V., Ruchirawat S., Prachayasittikul V. Roles of pyridine and pyrimidine derivatives as privileged scaffolds in anticancer agents. Mini-Reviews in Medicinal Chemistry. Vol 17, No.10 (2017), p.869-901. doi:10.2174/1389557516666160923125801 Retrieved from: https://hdl.handle.net/20.500.14740/4836

Title

Roles of pyridine and pyrimidine derivatives as privileged scaffolds in anticancer agents

Author(s)

Prachayasittikul S.
 Pingaew R.
 Worachartcheewan A.
 Sinthupoom N.
 Prachayasittikul V.
 Ruchirawat S.
 Prachayasittikul V.

Abstract

Background: Cancer has been considered to be a global health concern due to the impact of disease on the quality of life. The continual increase of cancer cases as well as the resistance of cancer cells to the existing drugs have driven the search for novel anticancer drugs with better potency and selectivity, improved pharmacokinetic profiles, and minimum toxicities. Pyridine and pyrimidine are presented in natural products and genetic materials. These pyridine/pyrimidine core structures have been noted for their roles in many biological processes as well as in cancer pathogenesis, which make such compounds become attractive scaffolds for discovery of novel drugs. Results & Conclusion: In the recent years, pyridine- and pyrimidine-based anticancer drugs have been developed based on structural modification of these core structures (i.e., substitution with moieties and rings, conjugation with other compounds, and coordination with metal ions). Detailed discussion is provided in this review to highlight the potential of these small molecules as privileged scaffolds with attractive properties and biological activities for the search of novel anticancer agents. © 2017 Bentham Science Publishers.

Subject(s)

1,2,3 triazole derivative
 1,4 naphthoquinone
 2,4 diphenoxy 6 aryl pyridine
 2,4 diphenoxy pyridine
 2,4 diphenoxyl 6 heteroaryl pyridine
 2,4 diphenyl 6 aryl pyridine
 2,4 diphenyl 6 heteroaryl pyridine
 2,4,6 triheteroaryl pyridine
 2,4,6 triphenyl pyridine
 2,6 diaminopyridine
 2,6 diphenyl 4 heteroaryl pyridine
 3 aminopicolinaldehyde thiosemicarbazone
 3 aminopyridine thiosemicarbazone
 3,5 disubstituted pyridine
 4 chromanone derivative
 Anthranilic acid
 Antineoplastic agent
 Coumarin
 Doxorubicin
 Isoflavone
 Nicotinamide
 Picoline derivative
 Pyridine derivative
 Pyrimidine derivative
 Quinoline
 Ribonucleotide reductase
 Tetrahydroisoquinoline
 Thiadiazole derivative
 Thiosemicarbazone derivative
 Unclassified drug
 Unindexed drug
 Antineoplastic agent
 Pyridine derivative
 Pyrimidine derivative
 A-549 cell line
 Antineoplastic activity
 Antiproliferative activity
 Apoptosis
 Breast cancer
 Cancer cell
 Cancer therapy
 Cell growth
 Cell survival
 Chronic myeloid leukemia
 Colorectal cancer
 DNA repair
 Erectile dysfunction
 Hep-G2 cell line
 IC50
 Kidney carcinoma
 Neoplasm
 Non small cell lung cancer
 Nonhuman
 Prostate cancer
 Quality of life
 Review
 Tumor suppressor gene
 Chemistry
 DNA damage
 Drug effects
 Human
 Structure activity relation
 Synthesis
 Antineoplastic Agents
 Cell Survival
 DNA Damage
 Humans
 Pyridines
 Pyrimidines
 Structure-Activity Relationship

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URI

https://hdl.handle.net/20.500.14740/4836

Collections

Scopus: Year 1983-2021

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Review

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