Publication: A prevalent caveolin-1 gene rs926198 variant is associated with type 2 diabetes mellitus in the Thai population
0
0
Issued Date
2024-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-85209477985
Pubmed ID
39528503
Journal Title
Scientific Reports
Volume
14
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports Vol.14 No.1 (2024)
Suggested Citation
Yaikwaong M., Ek-Eudomsuk P., Sittithumcharee G., Anupunpisit V., Peerapatdit T., Deerochanawong C., Himathongkam T., Jirawatnotai S., Chuengsamarn S. A prevalent caveolin-1 gene rs926198 variant is associated with type 2 diabetes mellitus in the Thai population. Scientific Reports Vol.14 No.1 (2024). doi:10.1038/s41598-024-78534-9 Retrieved from: https://hdl.handle.net/20.500.14740/20519
Corresponding Author(s)
Other Contributor(s)
Abstract
This study investigated the associations between CAV1 variants and metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiometabolic risk factors, as well as the influence of CAV1 variants on CAV1 mRNA expression. We genotyped 743 T2DM patients for CAV1 variants. Multiple logistic regression was conducted to adjust for sex, age, and body mass index (BMI), and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. The expression of mRNA was measured by reverse transcription polymerase chain reaction. The rs926198 variant, but not the rs3807989 variant, was associated with T2DM. Crude ORs were 1.87 (95% CI: 1.32–2.69, p = 0.0005) and adjusted ORs were 1.81 (95% CI: 1.12–2.96, p = 0.016), respectively. Additionally, patients with Mets and T2DM who had the rs926198 variant exhibited a significant 44.3% reduction in CAV1 mRNA expression (P < 0.05). Clinical samples revealed that the rs926198 variant is strongly linked to T2DM, with significantly reduced CAV1 mRNA. Our findings suggest a crucial role for the rs926198 variant in T2DM, indicating its potential for prevention, diagnosis, and intervention purposes.