Publication:
Lack of associations between TNF-α polymorphisms and cervical cancer in Thai women

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Issued Date

2016

Resource Type

Article

File Type

application/pdf

ISSN

15137368

DOI

10.7314/APJCP.2016.17.3.953

Other identifier(s)

2-s2.0-84965079449

Rights Holder(s)

Scopus

Bibliographic Citation

Asian Pacific Journal of Cancer Prevention. Vol 17, No.3 (2016), p.953-956

Suggested Citation

Chinchai T., Homchan K., Sopipong W., Chansaenroj J., Swangvaree S., Junyangdikul P., Vongpunsawad S., Poovorawan Y. Lack of associations between TNF-α polymorphisms and cervical cancer in Thai women. Asian Pacific Journal of Cancer Prevention. Vol 17, No.3 (2016), p.953-956. doi:10.7314/APJCP.2016.17.3.953 Retrieved from: https://hdl.handle.net/20.500.14740/5465

Title

Lack of associations between TNF-α polymorphisms and cervical cancer in Thai women

Author(s)

Chinchai T.
 Homchan K.
 Sopipong W.
 Chansaenroj J.
 Swangvaree S.
 Junyangdikul P.
 Vongpunsawad S.
 Poovorawan Y.

Abstract

The risk of developing cervical cancer in women infected with human papillomavirus (HPV) may be influenced by an individual's genetic susceptibility. Published data linking single nucleotide polymorphisms (SNPs) in the tumor necrosis factor-alpha (TNF-α) promoter region at positions-308G > A (rs1800629) and -238G > A (rs361525) to cervical cancer risk have been inconclusive. In this study, we examined 251 cervical specimens and classified them into two groups according to their cytological findings: 121 cancer cases and 130 controls (low-grade squamous intraepithelial lesion and normal cytology). All specimens were typed by PCR and sequencing for TNF-α promoter-308G > A (rs1800629) and -238G > A (rs361525). The genotype distribution of SNPs in either rs1800629 or rs361525 did not significantly demonstrate higher frequency in the cancer group (p=0.621 and p=0.68, respectively). Based on these results, neither the TNF-α promoter-308G > A (rs1800629) nor the -238G > A (rs361525) polymorphism presents a major risk factor for cervical cancer among Thai women. Larger studies are necessary to elucidate possible genetic mechanisms influencing cervical cancer development.

Subject(s)

Tumor necrosis factor
 Adult
 Aged
 Case control study
 Female
 Genetic predisposition
 Genetics
 Genotype
 Human
 Middle aged
 Papillomaviridae
 Pathogenicity
 Promoter region
 Risk factor
 Single nucleotide polymorphism
 Thailand
 Uterine cervix tumor
 Very elderly
 Virology
 Young adult
 Adult
 Aged
 Aged, 80 and over
 Case-Control Studies
 Female
 Genetic Predisposition to Disease
 Genotype
 Humans
 Middle Aged
 Papillomaviridae
 Polymorphism, Single Nucleotide
 Promoter Regions, Genetic
 Risk Factors
 Thailand
 Tumor Necrosis Factor-alpha
 Uterine Cervical Neoplasms
 Young Adult

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URI

https://hdl.handle.net/20.500.14740/5465

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Scopus: Year 1983-2021

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