Publication:
Restoration of lung microvasculature in diabetic condition after curcumin supplementation

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Issued Date

2017

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-85075006742

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 100, No.10 (2017), p.S40-S47

Suggested Citation

Anupunpisit V., Petpiboolthai H., Khanpetch P., Pramong R. Restoration of lung microvasculature in diabetic condition after curcumin supplementation. Journal of the Medical Association of Thailand. Vol 100, No.10 (2017), p.S40-S47. Retrieved from: https://hdl.handle.net/20.500.14740/4472

Title

Restoration of lung microvasculature in diabetic condition after curcumin supplementation

Author(s)

Anupunpisit V.
 Petpiboolthai H.
 Khanpetch P.
 Pramong R.

Abstract

Objective: To investigate the effect of curcumin in the restoration of lung microvasculature in streptozotocin-induced diabetic model. Material and Method: Operation of diabetic rat model was induced by streptozotocin (STZ: 60 mg/kg BW). Male rats (7 to 8 weeks old) have been classified into three groups, control (C), diabetic (DM) and diabetic rats supplemented with curcumin (DMC) (200 mg/kg BW). After 8 weeks, lung microvasculature was investigated under vascular corrosion cast technique and examined by scanning electron microscope (SEM). Results: In DM group, structural damages of pulmonary capillary level were obviously severe, defined as microangiopathy. The predominant abnormality of pulmonary capillary revealed destroyed characteristics such as shrinkage, constriction and capillary bed deformity. Furthermore, some destruction was observed at arteriole level whereas destructions of large and small arteries were rarely noticed. Regarding the diameters, the pulmonary capillary of DM group considerably decreased in sizes. Interestingly, upon curcumin supplementation, recovery of pulmonary capillary was predominantly enhanced, demonstrating reformed typical microvasculature pattern. Moreover, the diameter sizes of DMC pulmonary capillary were fully restored forward to normal control condition. Conclusion: Curcumin in diabetic rat could appreciably restored pulmonary microangiopathy at pulmonary capillary toward normal structure. Curcumin might be a novel therapeutic agent in pulmonary microvascular diabetic complications. © 2017 Medical Association of Thailand. All rights reserved.

Subject(s)

Bone morphogenetic protein receptor 2
 Curcumin
 Animal experiment
 Animal model
 Article
 Controlled study
 Corrosion casting
 Diabetes mellitus
 Lung arteriole
 Lung arteriole shrinkage
 Lung arteriole shrinkage
 Lung blood vessel
 Lung capillary
 Lung capillary deformity
 Lung capillary deformity
 Lung capillary shrinkage
 Lung capillary shrinkage
 Lung circulation
 Lung disease
 Male
 Microangiopathy
 Microvasculature
 Nonhuman
 Rat
 Scanning electron microscopy
 Streptozotocin-induced diabetes mellitus
 Supplementation

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URI

https://hdl.handle.net/20.500.14740/4472

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Scopus: Year 1983-2021

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