Publication:
Tuberculosis in Thai Renal Transplant Recipients: A 15-Year Experience

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Issued Date

2008

Resource Type

Article

File Type

application/pdf

ISSN

411345

DOI

10.1016/j.transproceed.2008.07.034

Other identifier(s)

2-s2.0-51249085414

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Transplantation Proceedings. Vol 40, No.7 (2008), p.2376-2379

Suggested Citation

Rungruanghiranya S., Ekpanyaskul C., Jirasiritum S., Nilthong C., Pipatpanawong K., Mavichak V. Tuberculosis in Thai Renal Transplant Recipients: A 15-Year Experience. Transplantation Proceedings. Vol 40, No.7 (2008), p.2376-2379. doi:10.1016/j.transproceed.2008.07.034 Retrieved from: https://hdl.handle.net/20.500.14740/3927

Title

Tuberculosis in Thai Renal Transplant Recipients: A 15-Year Experience

Author(s)

Rungruanghiranya S.
 Ekpanyaskul C.
 Jirasiritum S.
 Nilthong C.
 Pipatpanawong K.
 Mavichak V.

Abstract

Objective: Tuberculosis (TB) is a leading cause of morbidity and mortality in renal transplant recipients, especially in developing countries. Its incidence and characteristics remain unknown in Thai recipients. This study sought to determine the incidence, characteristics, risk factors, and outcome of TB in Thailand. Methods: We retrospectively reviewed case records of all renal transplant recipients from 1992 to 2007 to record demographic information, transplant characteristics, median time to diagnosis of TB, and outcomes. Results: Among 270 recipients, 9 (3.84%, 95% confidence interval [CI] 1.18%-5.49%) developed TB. Their median age was 40 years (range = 23-62 years) and median time from transplantation to diagnosis was 36 months (range = 4-115 months). Although pulmonary TB was the most common form (56%), 2 patients (22%) developed extrapulmonary disease. Disseminated TB occurred in 2 patients (22%). The diagnosis was made on respiratory specimen cultures in 3 cases (33.3%) and body fluid cultures in 3 (33.3%). Five patients (55.6%) were successfully treated with four-drug combination therapy. Two of the other subjects (22.2%) who received triple therapy were noncompliant, succumbing to graft failure and sepsis. Blood group AB (odds ratio [OR] 10.95, 95% CI 1.57-76.60) and use of tacrolimus rescue therapy (OR 9.68, 95% CI 2.13-43.94) were associated with an elevated risk of TB. Conclusion: TB is common among Thai renal transplant recipients with an incidence 27 times higher than that of the general Thai population. The extrapulmonary form in particular occurs more frequently with an increased risk of mortality. © 2008 Elsevier Inc. All rights reserved.

Subject(s)

Ethambutol
 Isoniazid
 Pyrazinamide
 Rifampicin
 Tacrolimus
 Adult
 Article
 Controlled study
 Extrapulmonary tuberculosis
 Female
 Graft failure
 Human
 Incidence
 Kidney transplantation
 Lung tuberculosis
 Major clinical study
 Male
 Miliary tuberculosis
 Priority journal
 Risk factor
 Sepsis
 Treatment outcome
 Tuberculosis
 Adolescent
 Adult
 Aged
 Child
 Female
 Humans
 Immunosuppressive Agents
 Kidney Transplantation
 Male
 Middle Aged
 Postoperative Complications
 Retrospective Studies
 Thailand
 Transplantation, Homologous
 Tuberculosis
 Tuberculosis, Pulmonary

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URI

https://hdl.handle.net/20.500.14740/3927

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Scopus: Year 1983-2021

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