Publication:
Long-term humoral and cellular immune response to hepatitis B vaccine in high-risk children 18-20 years after neonatal immunization

0
0

Issued Date

2009

Resource Type

Article

File Type

application/pdf

ISSN

8828245

DOI

10.1089/vim.2008.0087

Other identifier(s)

2-s2.0-65249109726

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Viral Immunology. Vol 22, No.2 (2009), p.125-130

Suggested Citation

Chinchai T., Chirathaworn C., Praianantathavorn K., Theamboonlers A., Hutagalung Y., Hans L. B.P., Thantiworasit P., Poovorawan Y. Long-term humoral and cellular immune response to hepatitis B vaccine in high-risk children 18-20 years after neonatal immunization. Viral Immunology. Vol 22, No.2 (2009), p.125-130. doi:10.1089/vim.2008.0087 Retrieved from: https://hdl.handle.net/20.500.14740/7297

Title

Long-term humoral and cellular immune response to hepatitis B vaccine in high-risk children 18-20 years after neonatal immunization

Author(s)

Chinchai T.
 Chirathaworn C.
 Praianantathavorn K.
 Theamboonlers A.
 Hutagalung Y.
 Hans L. B.P.
 Thantiworasit P.
 Poovorawan Y.

Abstract

Eighty-seven high-risk individuals in Thailand who had received a complete course of recombinant HBV vaccine 18-20 y ago were investigated with regard to their immunological memory. To evaluate humoral immunity, anti-HBs antibody titers were measured. Cellular immunity was determined by ELISPOT to detect HBV-specific IFN-γ-producing cells. Overall 83.9% of participants developed circulating anti-HBs (titer ≥ mIU/mL) and 58.6% were seroprotected (titer ≥10 mIU/mL). As for cellular immunity, 50.6% were positive on ELISPOT. Moreover, there was no correlation between the level of anti-HBs and positive ELISPOT results. However, the majority of participants (81.8%) who were positive for IFN-γ-producing cells were seropositive, but only 50% of seropositive participants were ELISPOT-positive. Thus, 18-20 y after immunization, it appears that a second booster dose should be considered, especially in high-risk groups. © Copyright 2009, Mary Ann Liebert, Inc.

Subject(s)

Alanine aminotransferase
 Aspartate aminotransferase
 Gamma interferon
 Hepatitis B antibody
 Recombinant hepatitis B vaccine
 Gamma interferon
 Hepatitis B antibody
 Hepatitis B vaccine
 Adult
 Alanine aminotransferase blood level
 Antibody blood level
 Antibody titer
 Article
 Aspartate aminotransferase blood level
 Cellular immunity
 Cytokine production
 Enzyme linked immunospot assay
 Female
 Hepatitis B
 Hepatitis B virus
 High risk population
 Human
 Human cell
 Humoral immunity
 Immunological memory
 Major clinical study
 Male
 Serology
 Thailand
 Adolescent
 Blood
 Hepatitis B
 Immunoassay
 Immunology
 Secretion
 T lymphocyte
 Hepatitis B virus
 Adolescent
 Hepatitis B
 Hepatitis B Antibodies
 Hepatitis B Vaccines
 Humans
 Immunoassay
 Immunologic Memory
 Interferon-gamma
 T-Lymphocytes
 Thailand
 Young Adult

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/7297

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By