Publication: Prevalence of thyroid diseases in familial adenomatous polyposis: a systematic review and meta-analysis
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Issued Date
2019
Resource Type
File Type
application/pdf
ISSN
13899600
Other identifier(s)
2-s2.0-85045426434
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Familial Cancer. Vol 18, No.1 (2019), p.53-62
Suggested Citation
Chenbhanich J., Atsawarungruangkit A., Korpaisarn S., Phupitakphol T., Osataphan S., Phowthongkum P. Prevalence of thyroid diseases in familial adenomatous polyposis: a systematic review and meta-analysis. Familial Cancer. Vol 18, No.1 (2019), p.53-62. doi:10.1007/s10689-018-0085-3 Retrieved from: https://hdl.handle.net/20.500.14740/5500
Abstract
Thyroid cancer (TC) is a known extra-intestinal manifestation and contributes to the mortality and morbidity in patients with familial adenomatous polyposis (FAP). Its exact prevalence is not well established and recent studies have shown an increasing number of TC in this patient population. The prevalence of benign thyroid masses and endocrinologic thyroid disorders are also poorly described. We conducted a systematic review and meta-analysis by using a random-effects model to characterize TC and estimated the prevalence of thyroid diseases in FAP patients. Twelve studies (n = 9821) were included. Pooled prevalence of TC, benign thyroid masses, and endocrinologic thyroid disorders in FAP were 2.6% [95% confidence interval (CI) 1.3–4.8], 48.8% [95% CI 33.8–64.0], and 6.9% [95% CI 4.5–10.3] respectively. Subgroup analyses revealed higher prevalence of TC in studies with fewer participants, studies that used screening ultrasound to diagnose TC, and studies that were published after 2002. TC diagnosis preceded the diagnosis of FAP in 34% of the patients. The means age at diagnosis of FAP and TC were 29 and 31 years, respectively. 95% of the patients were female and the most common pathology was of papillary subtype (83.3%). Most mutations (79.2%) were located at the 5′ end of APC gene. In summary, benign thyroid disorders are common in FAP, yet, TC is an uncommon phenomenon. Certain patient subset, such as young female with APC mutation at the 5′ end, might benefit from routine surveillance ultrasound. © 2018, Springer Science+Business Media B.V., part of Springer Nature.
Subject(s)
Article
Benign neoplasm
Confidence interval
Echography
Familial adenomatous polyposis
Human
Meta analysis
Priority journal
Sensitivity analysis
Systematic review
Thyroid cancer
Thyroid disease
Thyroid tumor
Adult
Age
Colon polyposis
Female
Genetics
Hyperthyroidism
Hypothyroidism
Male
Mutation
Prevalence
Sex factor
Thyroid tumor
APC protein
APC protein, human
Adenomatous Polyposis Coli
Adenomatous Polyposis Coli Protein
Adult
Age Factors
Female
Humans
Hyperthyroidism
Hypothyroidism
Male
Mutation
Prevalence
Sex Factors
Thyroid Neoplasms
Benign neoplasm
Confidence interval
Echography
Familial adenomatous polyposis
Human
Meta analysis
Priority journal
Sensitivity analysis
Systematic review
Thyroid cancer
Thyroid disease
Thyroid tumor
Adult
Age
Colon polyposis
Female
Genetics
Hyperthyroidism
Hypothyroidism
Male
Mutation
Prevalence
Sex factor
Thyroid tumor
APC protein
APC protein, human
Adenomatous Polyposis Coli
Adenomatous Polyposis Coli Protein
Adult
Age Factors
Female
Humans
Hyperthyroidism
Hypothyroidism
Male
Mutation
Prevalence
Sex Factors
Thyroid Neoplasms