Publication: Anterior segment optical coherence tomography characteristics of conjunctival papilloma as compared to papilliform ocular surface squamous neoplasia
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Issued Date
2023-04-01
Resource Type
ISSN
0950222X
eISSN
14765454
Scopus ID
2-s2.0-85142280891
Pubmed ID
36402855
Journal Title
Eye (Basingstoke)
Volume
37
Issue
5
Start Page
995
End Page
1001
Rights Holder(s)
SCOPUS
Bibliographic Citation
Eye (Basingstoke) Vol.37 No.5 (2023) , 995-1001
Suggested Citation
Sripawadkul W., Khzam R.A., Tang V., Zein M., Dubovy S.R., Galor A., Karp C.L. Anterior segment optical coherence tomography characteristics of conjunctival papilloma as compared to papilliform ocular surface squamous neoplasia. Eye (Basingstoke) Vol.37 No.5 (2023) , 995-1001. 1001. doi:10.1038/s41433-022-02309-7 Retrieved from: https://hdl.handle.net/20.500.14740/20013
Corresponding Author(s)
Other Contributor(s)
Abstract
Purpose: To describe the anterior segment optical coherence tomography (AS-OCT) appearance of conjunctival papilloma and identify differentiating features from papilliform ocular surface squamous neoplasia (OSSN). Method: A retrospective chart review of individuals clinically diagnosed with conjunctival papilloma (n = 10) or papilliform OSSN (n = 10) based on slit lamp features. Data on demographics, tumour characteristics, and primary treatment were collected. AS-OCT features were assessed including epithelial thickness and reflectivity, a corrugated epithelial surface, presence of an overhanging edge, presence of intrinsic spaces and posterior shadowing. Histopathology was available in 5 papilloma and 3 OSSN specimens. Result: Overall, the majority of individuals in both groups were white males. OSSN lesions were more likely to involve the limbus (80% vs.10%, p = 0.005) and the bulbar conjunctiva (100% vs. 20%, p < 0.001) compared to papillomas. On AS-OCT, maximum epithelial thickness was thicker in papilloma compared to OSSN (936 ± 533 vs. 637 ± 207 µm, p = 0.009). The feature that best differentiated papilloma from OSSN was an overhanging edge (100% vs. 0%, p < 0.001), where the epithelial lesion was seen on top of underlying normal epithelium. Other features more common in papilloma compared to OSSN included a corrugated epithelial surface (70% vs.10%, p = 0.02), the presence of intrinsic spaces (100% vs. 50%, p = 0.03), and posterior shadowing (100% vs. 40%, p = 0.01). Conclusion: AS-OCT shows differentiating features between papilloma and OSSN with an overhanging edge as a distinctive AS-OCT feature of papilloma.