Publication: The correlation of parathyroid hormone and heart rate variability in CAPD patients
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0
Issued Date
2013
Resource Type
File Type
application/pdf
ISSN
1252208
Other identifier(s)
2-s2.0-84877992723
Rights Holder(s)
Scopus
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol 96, No.5 (2013), p.595-602
Suggested Citation
Ussawawongaraya W., Spilles N., Nilwarangkoon S., Jariyapongskul A. The correlation of parathyroid hormone and heart rate variability in CAPD patients. Journal of the Medical Association of Thailand. Vol 96, No.5 (2013), p.595-602. Retrieved from: https://hdl.handle.net/20.500.14740/6654
Abstract
Objective: To investigate the correlation of parathyroid hormone (PTH) and cardiac autonomic nervous system (ANS) measured by heart rate variability (HRV) method in continuous ambulatory peritoneal dialysis (CAPD) patients. Material and Method: Healthy subjects (HS) and two groups of CAPD patients classified by the PTH concentration: high PTH group (H-PTH; PTH = 150-300 pg/ml) and ultra-high PTH group (UH-PTH; PTH >300 pg/ml) were studied. Time and frequency domains of HRV were analyzed. For the frequency domain, the fast Fourier transform of the total power (TP), low frequency (LF), high frequency (HF), and LF/HF ratio were transformed by natural logarithm (ln). The Pearson's correlation was used to analyze the correlation between lnPTH and the parameters of HRV. Results: Time and frequency domains of HS were at highest values whilst LF/HF ratio was the lowest. For UH-PTH CAPD patients, the values of standard deviation of R-R interval (SDNN), root mean square of the difference of R-R interval (RMSSD), lnTP and lnHF were significantly lower whereas lnLF was not significantly different compared to H-PTH. In addition, lnHF was found to have the highest negative correlation value with lnPTH concentration (r = -0.53). Conclusion: PTH, a serious uremic toxin, influences the initiation of ANS dysfunction. According to decreased lnHF, a decrease in parasympathetic activity was demonstrated in UH-PTH. Consequently, the modality that can stimulate the parasympathetic activity should be considered in CAPD patients who were hyperparathyroidism.
Subject(s)
Hemoglobin
Parathyroid hormone
Adult
Article
Autonomic nervous system
Continuous ambulatory peritoneal dialysis
Controlled study
Correlational study
Electrocardiography
Female
Heart rate variability
Human
Male
Vital sign
Adult
Autonomic Nervous System
Depression, Chemical
Female
Heart Rate
Humans
Hyperparathyroidism
Male
Middle Aged
Monitoring, Physiologic
Myocardial Contraction
Parathyroid Hormone
Peritoneal Dialysis, Continuous Ambulatory
Research Design
Statistics as Topic
Parathyroid hormone
Adult
Article
Autonomic nervous system
Continuous ambulatory peritoneal dialysis
Controlled study
Correlational study
Electrocardiography
Female
Heart rate variability
Human
Male
Vital sign
Adult
Autonomic Nervous System
Depression, Chemical
Female
Heart Rate
Humans
Hyperparathyroidism
Male
Middle Aged
Monitoring, Physiologic
Myocardial Contraction
Parathyroid Hormone
Peritoneal Dialysis, Continuous Ambulatory
Research Design
Statistics as Topic