Publication:
Effect of curcumin on liver fibrosis formation in rats with chronic inflammation following diabetics

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Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-85070548936

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 102, No.7 (2019), p.66-72

Suggested Citation

Pramong R., Satin K., Yang-En S., Petpiboolthai H., Anupunpisit V. Effect of curcumin on liver fibrosis formation in rats with chronic inflammation following diabetics. Journal of the Medical Association of Thailand. Vol 102, No.7 (2019), p.66-72. Retrieved from: https://hdl.handle.net/20.500.14740/5268

Title

Effect of curcumin on liver fibrosis formation in rats with chronic inflammation following diabetics

Author(s)

Pramong R.
 Satin K.
 Yang-En S.
 Petpiboolthai H.
 Anupunpisit V.

Abstract

Objective: To determine the effects of curcumin on the semiquantitative changes of inflammatory regulators; interleukin (IL)-13, tumor necrosis factor (TNF)-alpha, and ED1 as well as the type I and IV collagen levels in the liver of diabetic rats. Materials and Methods: Diabetic male rats were induced by streptozotocin intravenous injection (60 mg/kg BW). Rats were divided into three groups; control (C) group, diabetes (DM) group, and diabetes supplemented with curcumin (200 mg/kg BW) (DMC) group. After 12 weeks of curcumin supplementation, the liver tissues were collected. The levels of IL-13, TNF-alpha, type I collagen, and type IV collagen were analyzed by western blot analysis, while the level of ED1, a marker of hepatic macrophages, was analyzed by immunohistochemical method. Results: The levels of IL-13, TNF-alpha, type I collagen, and type IV collagen were markedly elevated in the DM group compared to the control group. In contrast, the levels of these entire proteins were decreased significantly in the DMC group. In addition, the level of ED1-immunoreactivity significantly decreased in DMC group compared to that in the DM group. Conclusion: The present results support the hypothesis that curcumin can reduce hepatic inflammation and fibrosis in diabetic liver tissues. Therefore, dietary curcumin might have efficacy to ameliorate diabetic-induced hepatic injury in terms of anti-inflammation and antifibrotic properties. © JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND| 2019.

Subject(s)

CD68 antigen
 Collagen type 1
 Collagen type 4
 Curcumin
 Interleukin 13
 Tumor necrosis factor
 Animal cell
 Animal experiment
 Animal model
 Animal tissue
 Antiinflammatory activity
 Article
 Controlled study
 Diabetes mellitus
 Hepatic stellate cell
 Immunohistochemistry
 Immunoprecipitation
 Immunoreactivity
 Inflammation
 Kupffer cell
 Liver cell
 Liver fibrosis
 Liver injury
 Macrophage
 Male
 Nonhuman
 Oxidative stress
 Protein expression
 Rat
 Streptozotocin-induced diabetes mellitus
 Western blotting

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https://hdl.handle.net/20.500.14740/5268

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Scopus: Year 1983-2021

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