Publication: Formulation and chemical composition of aromatherapy product for antioxidant
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Issued Date
2020
Resource Type
File Type
application/pdf
ISSN
9752366
Other identifier(s)
2-s2.0-85090178055
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
International Journal of Pharmaceutical Research. Vol 12, (2020), p.1892-1900
Suggested Citation
Hongratanaworakit T., Malai W., Ubolviroj S., Ketsanchai R., Wuthisakon S., Tadtong S. Formulation and chemical composition of aromatherapy product for antioxidant. International Journal of Pharmaceutical Research. Vol 12, (2020), p.1892-1900. doi:10.31838/ijpr/2020.SP1.282 Retrieved from: https://hdl.handle.net/20.500.14740/4750
Abstract
Free radicals are one cause of wrinkles. Adding antioxidants to the skin is one option to decrease wrinkles or slow the aging process. Up to now, research in aromatherapy product development for antioxidants has rarely been published. Therefore, the objectives of this study were: (i) to analyze the chemical composition of blended essential oil formula (BEOF) (ii) to develop an aromatherapy product containing natural oils for antioxidants (iii) to evaluate product user satisfaction and to test product safety in humans. The chemical composition of BEOF was determined by gas chromatography-mass spectrometry (GC/MS). Antioxidant activities were tested by the DPPH and ABTS Free-Radical Scavenging Assays. Three essential oils were used as active ingredients. Eight fixed natural oils were used as base oils and the product's preliminary physicochemical stability was evaluated for two months. The product's satisfaction was then evaluated by 30 users in terms of physical properties, user feelings, and user satisfaction. Safety tests were investigated by A Kligman maximization method. The results showed that the BEOF consisting of lavender: clary sage: ylang ylang oils (2:4:4) in a volume ratio provided the highest antioxidant activity. The BEOF mainly contained linalyl acetate and linalool. The blended base oil formula 1 (BBF1) composed of sweet almond, grapeseed, avocado, and jojoba oils provided strong antioxidant activity. The aromatherapy product F1 composed of BEOF, vitamin E acetate, and BBF1 demonstrated strong antioxidant activity and good physical appearance. Furthermore, the resulting aromatherapy product remained stable for two months and was safe after two weeks of use. Our findings represent the potentiality to use this aromatherapy product as an antioxidant to slow the aging process. © 2020, Advanced Scientific Research. All rights reserved.
Subject(s)
Alpha tocopherol
Antioxidant
Essential oil
Linalool
Plant medicinal product
Ylang ylang oil
ABTS radical scavenging assay
Aging
Antioxidant activity
Aromatherapy
Article
Cananga
Cananga odorata
Chemical composition
DPPH radical scavenging assay
Drug formulation
Drug stability
Human
IC50
Lavandula angustifolia
Mass fragmentography
Mass spectrometry
Normal human
Patient satisfaction
Physical appearance
Physical chemistry
Salvia
Salvia sclarea
Skin irritation
Skin sensitization
Antioxidant
Essential oil
Linalool
Plant medicinal product
Ylang ylang oil
ABTS radical scavenging assay
Aging
Antioxidant activity
Aromatherapy
Article
Cananga
Cananga odorata
Chemical composition
DPPH radical scavenging assay
Drug formulation
Drug stability
Human
IC50
Lavandula angustifolia
Mass fragmentography
Mass spectrometry
Normal human
Patient satisfaction
Physical appearance
Physical chemistry
Salvia
Salvia sclarea
Skin irritation
Skin sensitization