Publication:
Polylactide-based materials science strategies to improve tissue-material interface without the use of growth factors or other biological molecules

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Issued Date

2019

Resource Type

Review

File Type

application/pdf

ISSN

9284931

DOI

10.1016/j.msec.2018.09.038

Other identifier(s)

2-s2.0-85053931733

Rights Holder(s)

Scopus

Bibliographic Citation

Materials Science and Engineering C. Vol 94, (2019), p.1083-1101

Suggested Citation

Gritsch L., Conoscenti G., La Carrubba V., Nooeaid P., Boccaccini A.R. Polylactide-based materials science strategies to improve tissue-material interface without the use of growth factors or other biological molecules. Materials Science and Engineering C. Vol 94, (2019), p.1083-1101. doi:10.1016/j.msec.2018.09.038 Retrieved from: https://hdl.handle.net/20.500.14740/5737

Title

Polylactide-based materials science strategies to improve tissue-material interface without the use of growth factors or other biological molecules

Author(s)

Gritsch L.
 Conoscenti G.
 La Carrubba V.
 Nooeaid P.
 Boccaccini A.R.

Abstract

In a large number of medical devices, a key feature of a biomaterial is the ability to successfully bond to living tissues by means of engineered mechanisms such as the enhancement of biomineralization on a bone tissue engineering scaffold or the mimicking of the natural structure of the extracellular matrix (ECM). This ability is commonly referred to as “bioactivity”. Materials sciences started to grow interest in it since the development of bioactive glasses by Larry Hench five decades ago. As the main goal in applications of biomedical devices and tissue scaffolds is to obtain a seamless tissue-material interface, achieving optimal bioactivity is essential for the success of most biomaterial-based tissue replacement and regenerative approaches. Polymers derived from lactic acid are largely adopted in the biomedical field, they are versatile, FDA approved and relatively cost-effective. However, as for many other widespread biomedical polymers, they are hydrophobic and lack the intrinsic ability of positively interacting with surrounding tissues. In the last decades scientists have studied many solutions to exploit the positive characteristics of polylactide-based materials overcoming this bottleneck at the same time. The efforts of this research fruitfully produced many effective tissue engineering technologies based on PLA and related biopolymers. This review aims to give an overview on the latest and most promising strategies to improve the bioactivity of lactic acid-based materials, especially focusing on biomolecule-free bulk approaches such as blending, copolymerization or composite fabrication. Avenues for future research to tackle current needs in the field are identified and discussed. © 2018 Elsevier B.V.

Subject(s)

Bioactive glass
 Bioactivity
 Biomedical equipment
 Biomineralization
 Biomolecules
 Biopolymers
 Blending
 Composite materials
 Cost effectiveness
 Functional polymers
 Growth (materials)
 Histology
 Interfaces (materials)
 Lactic acid
 Polyesters
 Scaffolds
 Scaffolds (biology)
 Structure (composition)
 Tissue engineering
 Biological molecule
 Biomedical devices
 Biomedical polymers
 Bone tissue engineering
 Composite fabrication
 Extracellular matrices
 Material interfaces
 Poly lactic acid
 Tissue
 Polyester
 Polylactide
 Signal peptide
 Animal
 Chemistry
 Human
 Materials science
 Synthesis
 Tissue engineering
 Tissue scaffold
 Animals
 Humans
 Intercellular Signaling Peptides and Proteins
 Materials Science
 Polyesters
 Tissue Engineering
 Tissue Scaffolds

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URI

https://hdl.handle.net/20.500.14740/5737

Collections

Scopus: Year 1983-2021

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Review

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