Publication:
Pancreatic neuroendocrine tumor, lymphoma, and squamous cell carcinoma of hypopharynx; A case report of three primary cancers in one patient

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Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

22102612

DOI

10.1016/j.ijscr.2019.10.073

Other identifier(s)

2-s2.0-85074370143

Rights Holder(s)

Scopus

Bibliographic Citation

International Journal of Surgery Case Reports. Vol 65, (2019), p.111-114

Suggested Citation

Tangsirapat V., Wongta K., Chakrapan Na Ayudhya K., Chakrapan Na Ayudhya V., Sookpotarom P. Pancreatic neuroendocrine tumor, lymphoma, and squamous cell carcinoma of hypopharynx; A case report of three primary cancers in one patient. International Journal of Surgery Case Reports. Vol 65, (2019), p.111-114. doi:10.1016/j.ijscr.2019.10.073 Retrieved from: https://hdl.handle.net/20.500.14740/5697

Title

Pancreatic neuroendocrine tumor, lymphoma, and squamous cell carcinoma of hypopharynx; A case report of three primary cancers in one patient

Author(s)

Tangsirapat V.
 Wongta K.
 Chakrapan Na Ayudhya K.
 Chakrapan Na Ayudhya V.
 Sookpotarom P.

Abstract

Background: Pancreatic neuroendocrine tumors (PNETs) are rarely found and the majority of PNETs are nonfunctioning. At present, a patient with pancreatic neuroendocrine tumor (PNET), lymphoma, and squamous cell carcinoma (SCC) occurring simultaneously has not been reported. We presented all these three primary cancers in a same patient. Case presentation: A 51-year-old male presented with a right testicular mass for four months. He underwent right orchidectomy, and the patient was diagnosed malignant diffuse large B-cell lymphoma. Consequently, CHOP regimen and intrathecal methotrexate were given as treatment. During the metastasis work up, a hypodense lesion at the tail of pancreas was found. Distal pancreatectomy and splenectomy were completed, and the pathological report revealed PNET. Eighteen months later, the patient developed a symptom of odynophagia, direct laryngoscopy was performed and a mass at the left arytenoid was found. The biopsy was done and confirmed the diagnosis of SCC. The patient went through concurrent chemo-radiation with a complete response. Currently the patient remains in a complete remission of all three cancers. Discussion: As the patient had non-functioning PNET and was symptom-free, the diagnosis would have not been discovered without the metastasis workup of lymphoma. Although non-functioning PNET less than 2 cm can be safely observed, the tumor was 4.3 × 1.3 cm and adenocarcinoma was suspected, so the patient underwent the surgery. Conclusion: Although many cases with multiple primary cancers have been published, a case of patient with PNET, lymphoma, and SCC occurring as primary cancers has not been yet reported. © 2019 The Author(s)

Subject(s)

CD20 antigen
 Ki 67 antigen
 Methotrexate
 Neuron specific enolase
 Receptor type tyrosine protein phosphatase C
 Synaptophysin
 Adult
 Antigen expression
 Article
 Axillary lymph node
 Cancer adjuvant therapy
 Cancer diagnosis
 Cancer regression
 Cancer staging
 Case report
 Chemoradiotherapy
 Clinical article
 Computer assisted tomography
 Diabetes mellitus
 Diffuse large B cell lymphoma
 Distal pancreatectomy
 Human
 Hypertension
 Hypopharynx squamous cell carcinoma
 Immunohistochemistry
 Incidental finding
 Inguinal region
 Lymphadenopathy
 Male
 Medical history
 Middle aged
 Odynophagia
 Orchiectomy
 Pancreas islet cell tumor
 Priority journal
 Radiation response
 Smoking
 Splenectomy
 Surgical margin
 Testis tumor

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URI

https://hdl.handle.net/20.500.14740/5697

Collections

Scopus: Year 1983-2021

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