Publication:
Intramuscular anti-D in chronic immune thrombocytopenia children with severe thrombocytopenia

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Issued Date

2013

Resource Type

Article

File Type

application/pdf

ISSN

13288067

DOI

10.1111/ped.12179

Other identifier(s)

2-s2.0-84890443282

Rights Holder(s)

Scopus

Bibliographic Citation

Pediatrics International. Vol 55, No.6 (2013), p.e146-e148

Suggested Citation

Sirachainan N., Anurathapan U., Chuansumrit A., Songdej D., Wongwerawattanakoon P., Hutspardol S., Kitpoka P. Intramuscular anti-D in chronic immune thrombocytopenia children with severe thrombocytopenia. Pediatrics International. Vol 55, No.6 (2013), p.e146-e148. doi:10.1111/ped.12179 Retrieved from: https://hdl.handle.net/20.500.14740/6499

Title

Intramuscular anti-D in chronic immune thrombocytopenia children with severe thrombocytopenia

Author(s)

Sirachainan N.
 Anurathapan U.
 Chuansumrit A.
 Songdej D.
 Wongwerawattanakoon P.
 Hutspardol S.
 Kitpoka P.

Abstract

Nine patients with chronic immune thrombocytopenia and platelet counts <20 × 109/L, with a median age of 7.8 (3.8-15.5) years, received three phases of 10 mcg/kg/dose of intramuscular anti-D. Phase 1 was anti-D daily for 5 days, followed by phase 2, anti-D weekly for 12 weeks and withheld when platelet counts ≥20 × 109/L, and then phase 3 was anti-D once every 2 weeks for 24 weeks. According to the International Working Group criteria, in phase 1, 66.7% of patients responded to the treatment. In phases 2 and 3, 11.1% (0-41.7%) and 7.7% (0-33.3%) of total episodes of follow up, respectively, responded to the treatment. Therefore, intramuscular anti-D given at a dose of 10 mcg/kg for 5 days is an alternative method to raise platelet counts in chronic immune thrombocytopenia children with severe thrombocytopenia where the intravenous form of anti-D is not available. © 2013 Japan Pediatric Society.

Subject(s)

Igamed
 Immunoglobulin
 Methotrexate
 Methylprednisolone
 Prednisolone
 Rhesus D antibody
 Unclassified drug
 Vincristine
 Alloantibody
 RHO(D) antibody
 Adolescent
 Article
 Child
 Chronic immune thrombocytopenia
 Clinical article
 Disease severity
 Female
 Follow up
 Human
 Male
 Preschool child
 Priority journal
 School child
 Thrombocyte count
 Thrombocytopenia
 Treatment response
 Intramuscular drug administration
 Purpura, Thrombocytopenic, Idiopathic
 Severity of illness index
 Adolescent
 Child
 Child, Preschool
 Female
 Humans
 Injections, Intramuscular
 Isoantibodies
 Male
 Purpura, Thrombocytopenic, Idiopathic
 Severity of Illness Index

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URI

https://hdl.handle.net/20.500.14740/6499

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Scopus: Year 1983-2021

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