Publication:
Behavioral effects of acute and chronic oral administration of barakol in rats.

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Issued Date

2009

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-77957307242

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of the Medical Association of Thailand = Chotmaihet thangphaet. Vol 92 Suppl 3, No. (2009), p.S29-37

Suggested Citation

Deachapunya C., Thongsaard W. Behavioral effects of acute and chronic oral administration of barakol in rats.. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. Vol 92 Suppl 3, No. (2009), p.S29-37. Retrieved from: https://hdl.handle.net/20.500.14740/7703

Title

Behavioral effects of acute and chronic oral administration of barakol in rats.

Author(s)

Deachapunya C.
 Thongsaard W.

Abstract

INTRODUCTION: Barakol, an active constituent extracted from Cassia siamea, has been shown to have anxiolytic effects similar to diazepam when treated intraperitoneally. OBJECTIVE: Acute and chronic oral administrations of barakol on anxiolytic, locomotor and exploratory behaviors were examined in rats using an elevated plus maze followed by a holeboard apparatus in comparison with the anxiolytic diazepam. MATERIAL AND METHOD: Male Wistar rats were divided into the acute and chronic treatment groups. The acutely-treated rats were given orally with vehicle control (distilled water, p.o.), diazepam (5 mg/kg, p.o.) and barakol (10, 30 and 100 mg/kg, p.o.) while the chronically-treated rats received the same treatment for 30 consecutive days. The anxiolytic behavior was tested on the elevated plus maze for 5 min and immediately followed by the holeboard to test for the directed exploratory behavior for 10 min. RESULTS: Acute and chronic oral administration of barakol (10, 30 and 100 mg/kg, p.o.) produced no significant changes in anxiolytic parameters tested on the elevated plus maze compared to diazepam which significantly increased the percentage of the open/total time and the time spent on the open arms. On the other hand, all parameters tested using the holeboard were not affected by barakol or diazepam when given acutely. When given chronically, all doses of barakol significantly decreased the number of head-dips and the total time spent head-dipping with no changes in the number of grooms or rears per minute. CONCLUSION: Acute and chronic oral administration of barakol had no anxiolytic and locomotor effects. However, it exerted a sedative effect as shown by a reduction in the directed exploratory behaviors.

Subject(s)

Anxiolytic agent
 Barakol
 Benzopyran derivative
 Diazepam
 Phenalene derivative
 Plant extract
 Acute disease
 Animal
 Animal behavior
 Anxiety
 Article
 Chronic disease
 Drug effect
 Human
 Oral drug administration
 Phytotherapy
 Rat
 Senna
 Wistar rat
 Acute Disease
 Administration, Oral
 Animals
 Anti-Anxiety Agents
 Anxiety
 Behavior, Animal
 Benzopyrans
 Chronic Disease
 Diazepam
 Humans
 Phenalenes
 Phytotherapy
 Plant Extracts
 Rats
 Rats, Wistar
 Senna Plant

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URI

https://hdl.handle.net/20.500.14740/7703

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Scopus: Year 1983-2021

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