Publication:
Therapeutic implications of human endothelial nitric oxide synthase gene polymorphism

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0

Issued Date

2001

Resource Type

Review

File Type

application/pdf

ISSN

1656147

DOI

10.1016/S0165-6147(00)01692-8

Other identifier(s)

2-s2.0-0035398540

Rights Holder(s)

Scopus

Bibliographic Citation

Trends in Pharmacological Sciences. Vol 22, No.7 (2001), p.361-368

Suggested Citation

Wattanapitayakul S.K., Mihm M.J., Young A.P., Bauer J.A. Therapeutic implications of human endothelial nitric oxide synthase gene polymorphism. Trends in Pharmacological Sciences. Vol 22, No.7 (2001), p.361-368. doi:10.1016/S0165-6147(00)01692-8 Retrieved from: https://hdl.handle.net/20.500.14740/6900

Title

Therapeutic implications of human endothelial nitric oxide synthase gene polymorphism

Author(s)

Wattanapitayakul S.K.
 Mihm M.J.
 Young A.P.
 Bauer J.A.

Abstract

Vascular endothelial dysfunction is now recognized as a common phenomenon in an array of cardiovascular disorders. Production of nitric oxide via the endothelial isoform of nitric oxide synthase [eNOS (previously termed NOS3 or ecNOS)] is vital for a healthy endothelium; several polymorphic variations of the gene encoding eNOS (NOS3) are now known and have been investigated with respect to disease risk. Surprisingly, only approximately half of these studies have demonstrated significant associations between NOS3 polymorphisms and cardiovascular disease, and many reports are contradictory. Central issues include adequate statistical power, appropriateness of control cohorts, multigene interactions and plausible biological consequences. So far, the inconsistencies are not unique to the NOS3 polymorphisms, but probably represent the broad challenges in defining genetic aspects of complex disease processes.

Subject(s)

Amino acid
 Cysteine
 Glycine
 Isoprotein
 Nitric oxide
 Nitric oxide synthase
 Threonine
 Artery endothelium
 Cardiovascular disease
 Cardiovascular risk
 Disease course
 DNA flanking region
 Drug specificity
 Environmental factor
 Enzyme activity
 Exon
 Gene therapy
 Genetic code
 Genetic variability
 Human
 Intron
 Multigene family
 Priority journal
 Promoter region
 Protein stability
 Review
 Single nucleotide polymorphism
 Arginine
 Cardiovascular Diseases
 Exons
 Humans
 Linkage Disequilibrium
 Nitric Oxide Donors
 Nitric Oxide Synthase
 Nitric Oxide Synthase Type III
 Polymorphism, Genetic
 Variation (Genetics)

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URI

https://hdl.handle.net/20.500.14740/6900

Collections

Scopus: Year 1983-2021

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