Publication:
The association of serum magnesium and mortality outcomes in heart failure patients: A systematic review and meta-analysis

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Issued Date

2016

Resource Type

Review

File Type

application/pdf

ISSN

257974

DOI

10.1097/MD.0000000000005406

Other identifier(s)

2-s2.0-85007508449

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Medicine (United States). Vol 95, No.50 (2016)

Suggested Citation

Angkananard T., Anothaisintawee T., Eursiriwan S., Gorelik O., Mcevoy M., Attia J., Thakkinstian A. The association of serum magnesium and mortality outcomes in heart failure patients: A systematic review and meta-analysis. Medicine (United States). Vol 95, No.50 (2016). doi:10.1097/MD.0000000000005406 Retrieved from: https://hdl.handle.net/20.500.14740/5978

Title

The association of serum magnesium and mortality outcomes in heart failure patients: A systematic review and meta-analysis

Author(s)

Angkananard T.
 Anothaisintawee T.
 Eursiriwan S.
 Gorelik O.
 Mcevoy M.
 Attia J.
 Thakkinstian A.

Abstract

Background: Low serum magnesium (Mg) has been independently shown to increase risk of heart failure (HF), but data on the association between serum Mg concentration and the outcome of patients with HF are conflicting. The purpose of this systematic review and meta-analysis was to estimate the prognostic effects of hypermagnesemia and hypomagnesemia on cardiovascular (CV) mortality and all-cause mortality (ACM) of patients with HF. Methods: Relevant studies were identified from Medline and Scopus databases. Included and excluded criteria were defined. Effects (i.e., log [risk ratio [RR]]) of hypomagnesemia and hypermagnesemia versus normomagnesemia were estimated using Poisson regression, and then a multivariate meta-analysis was applied for pooling RRs across studies. Heterogeneity was explored using a meta-regression and subgroup analysis. Results: On analysis, 7 eligible prospective studies yielded a total of 5172 chronic HF patients with 913 and 1438 deaths from CV and ACM, respectively. Most participants were elderly men with left ventricular (LV) ejection fraction ≤40%. Those patients with baseline hypermagnesemia had a significantly higher risk of CV mortality (RR, 1.38; 95% confidence interval [CI], 1.07-1.78) or ACM (RR, 1.35; 95% CI, 1.18-1.54) than those with baseline normomagnesemia. However, baseline hypomagnesemia was not associated with the risk of CV mortality (RR, 1.11; 95% CI, 0.79-1.57) and ACM (RR, 1.11; 95% CI, 0.87-1.41). A subgroup analysis by Mg cutoff suggested a dose-response trend for hypermagnesemia effects, that is, the pooled RRs for CV mortality were 1.28 (95% CI, 1.05-1.55) and 1.92 (95% CI, 1.00-3.68) for the cutoff of 0.89 to 1.00 and 1.05 to 1.70 mmol/L, respectively. Conclusion: The present systematic review and meta-analysis suggested that, in HF patients, hypermagnesemia with serum Mg=1.05mmol/L was associated with an increased risk of CV mortality and ACM but this was not observed for hypomagnesemia. This finding was limited to the elderly patients with chronic HF who had reduced LV systolic function. © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved.

Subject(s)

Magnesium
 Biological marker
 Magnesium
 Diuretic agent
 Cardiovascular mortality
 Cerebrovascular accident
 Heart ejection fraction
 Heart failure
 Heart infarction
 Human
 Hypermagnesemia
 Hypomagnesemia
 Ischemic heart disease
 Magnesium blood level
 Meta analysis
 Outcome assessment
 Priority journal
 Prognosis
 Randomized controlled trial (topic)
 Review
 Sudden death
 Systematic review
 Age
 Aged
 Blood
 Cause of death
 Disease course
 Female
 Heart failure
 Male
 Middle aged
 Mortality
 Pathophysiology
 Prospective study
 Severity of illness index
 Sex difference
 Survival analysis
 Very elderly
 All cause mortality
 Cardiovascular risk
 Cause of death
 Disease association
 Dose response
 Heart left ventricle ejection fraction
 High risk patient
 Hypermagnesemia
 Hypomagnesemia
 Medline
 Mortality rate
 Risk assessment
 Risk factor
 Scopus
 Age Factors
 Aged
 Aged, 80 and over
 Biomarkers
 Cause of Death
 Disease Progression
 Female
 Heart Failure
 Humans
 Magnesium
 Male
 Middle Aged
 Prospective Studies
 Severity of Illness Index
 Sex Factors
 Survival Analysis

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URI

https://hdl.handle.net/20.500.14740/5978

Collections

Scopus: Year 1983-2021

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Review

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