Publication:
Effect of daily treatment with Thai herb, Kaempferia parviflora, in Hershberger assay using castrated immature rats

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Issued Date

2007

Resource Type

Article

File Type

application/pdf

ISSN

9168818

DOI

10.1262/jrd.18092

Other identifier(s)

2-s2.0-34248340060

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Reproduction and Development. Vol 53, No.2 (2007), p.351-356

Suggested Citation

Trisomboon H., Watanabe G., Wetchasit P., Taya K. Effect of daily treatment with Thai herb, Kaempferia parviflora, in Hershberger assay using castrated immature rats. Journal of Reproduction and Development. Vol 53, No.2 (2007), p.351-356. doi:10.1262/jrd.18092 Retrieved from: https://hdl.handle.net/20.500.14740/4712

Title

Effect of daily treatment with Thai herb, Kaempferia parviflora, in Hershberger assay using castrated immature rats

Author(s)

Trisomboon H.
 Watanabe G.
 Wetchasit P.
 Taya K.

Abstract

The aim of the present study was to investigate the testosterone-like effect of Kaempferia parviflora (KP). Castrated immature rats were randomized and divided into two groups (control and KP-treatment groups). The rats (n=7-8) were treated daily for 5 days by oral route with water in the control group and 1,000 mg/kg of KP in the treatment group. All rats were decapitated 24 h after their last dose and then blood samples were collected for assay of serum FSH, LH, testosterone, progesterone and corticosterone levels. The seminal vesicles plus coagulating glands, ventral prostate, levator ani muscle plus bulbocavernosus muscle, glans penis, kidneys and the adrenal glands were collected and weighed for organ wet weight. Body weight and weight of food intake were recorded throughout the study period. The results show that relative body weight gain in the KP-treatment group was significantly increased 24 and 48 h after the first dose (P<0.05) and then was indistinguishable from the control group. There were no significant differences in the relative reproductive and non-reproductive organ weights between the groups, although all organ weights, except for the glans penis, tended to increase in the KP-treatment group. The serum testosterone levels were significantly increased in the KP-treatment group. There were no significant differences in the serum FSH, LH, progesterone, or corticosterone levels between the groups, even though the serum progesterone level tended to increase and serum LH level tended to decrease in the KP-treatment group. The present study indicates that KP has no testosterone-like effect on reproduction in male rats.

Subject(s)

Corticosterone
 Follitropin
 Luteinizing hormone
 Plant extract
 Progesterone
 Testosterone
 Animal
 Article
 Bioassay
 Blood
 Body weight
 Dose response
 Drug effect
 Eating
 Male
 Male genital system
 Medicinal plant
 Methodology
 Orchiectomy
 Organ size
 Rat
 Thailand
 Wistar rat
 Zingiberaceae
 Animals
 Biological Assay
 Body Weight
 Corticosterone
 Dose-Response Relationship, Drug
 Eating
 Follicle Stimulating Hormone
 Genitalia, Male
 Luteinizing Hormone
 Male
 Orchiectomy
 Organ Size
 Plant Extracts
 Plants, Medicinal
 Progesterone
 Rats
 Rats, Wistar
 Testosterone
 Thailand
 Zingiberaceae
 Glans
 Kaempferia parviflora
 Rattus

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URI

https://hdl.handle.net/20.500.14740/4712

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Scopus: Year 1983-2021

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