Publication:
Anti-xanthine oxidase activity of flavone analogues from dillenia indica L. And in silico study

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Issued Date

2019

Resource Type

Article

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application/pdf

ISSN

9741496

DOI

10.31788/RJC.2019.1245412

Other identifier(s)

2-s2.0-85076306625

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Rasayan Journal of Chemistry. Vol 12, No.4 (2019), p.2273-2283

Suggested Citation

Khammee T., Rattanapittayapron A., Rangjaroen C., Jaratrungtawee A., Kuno M. Anti-xanthine oxidase activity of flavone analogues from dillenia indica L. And in silico study. Rasayan Journal of Chemistry. Vol 12, No.4 (2019), p.2273-2283. doi:10.31788/RJC.2019.1245412 Retrieved from: https://hdl.handle.net/20.500.14740/5137

Title

Anti-xanthine oxidase activity of flavone analogues from dillenia indica L. And in silico study

Author(s)

Khammee T.
 Rattanapittayapron A.
 Rangjaroen C.
 Jaratrungtawee A.
 Kuno M.

Abstract

Six bioactive substances have been isolated from the fruit extract of Dillenia indica L., including a triterpene lupeol (1), together with a mixture of β-sitosterol (2a) and stigmasterol (2b), three flavonols, keamferide (3), dillenetin (4), quercetin (5), and β-sitosterol-d-glucoside (6). The structures of all isolated compounds were characterized by analysis of their spectroscopic data and by comparison with the reported value of the known compounds. The investigation of anti-xanthine oxidase activity shows that compounds 3, 4, and 5 were suitable xanthine oxidase inhibitors, with IC50 value in the range of 0.56-1.44 mM. Moreover, a molecular docking study of a potent xanthine oxidase inhibitor was performed to find the binding mode of the inhibitors into the binding site of xanthine oxidase. © RASĀYAN. All rights reserved.

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URI

https://hdl.handle.net/20.500.14740/5137

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Scopus: Year 1983-2021

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