Publication:
Comparison of the efficacy and safety of 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of childhood acanthosis nigricans

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Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

7368046

DOI

10.1111/pde.13799

Other identifier(s)

2-s2.0-85065863410

Rights Holder(s)

Scopus

Bibliographic Citation

Pediatric Dermatology. Vol 36, No.3 (2019), p.330-334

Suggested Citation

Treesirichod A., Chaithirayanon S., Wongjitrat N. Comparison of the efficacy and safety of 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of childhood acanthosis nigricans. Pediatric Dermatology. Vol 36, No.3 (2019), p.330-334. doi:10.1111/pde.13799 Retrieved from: https://hdl.handle.net/20.500.14740/5349

Title

Comparison of the efficacy and safety of 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of childhood acanthosis nigricans

Author(s)

Treesirichod A.
 Chaithirayanon S.
 Wongjitrat N.

Abstract

Background: There have been few published randomized controlled trials for the treatment of childhood acanthosis nigricans (AN) to date. Objective: To assess the efficacy of topical 0.1% adapalene gel compared to 0.025% tretinoin cream in the treatment of childhood AN. Methods: An 8-week, randomized, split-neck, comparative study between topical 0.1% adapalene gel and 0.025% tretinoin cream for the treatment of neck hyperpigmentation associated with AN was performed. M index measured by a narrowband reflectance spectrophotometer and both investigator's global evaluation (IGE) and parent's global evaluation (PGE) scales were used to evaluate efficacy. Results: There was no statistically significant difference between 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of AN-associated hyperpigmentation (P = 0.56). Mean differences in M indices between week 0 and week 8 of 0.1% adapalene and 0.025% tretinoin treatment were 24.2 ± 7.9% and 23.8 ± 8.3% improvement, respectively. Regarding treatment efficacy, 90.0% and 85.0% of participants had more than 75% improvement in IGE in 0.1% adapalene and 0.025% tretinoin treatment sides, respectively. In addition, 75.0% and 65.0% of participants had more than 75.0% improvement in PGE in 0.1% adapalene and 0.025% tretinoin treatment sides, respectively. Limitations: Lack of histopathological evaluations. Conclusions: We found no significant difference between topical 0.1% adapalene gel and 0.025% tretinoin in the treatment of AN. © 2019 Wiley Periodicals, Inc.

Subject(s)

Adapalene
 Retinoic acid
 Adapalene
 Dermatological agent
 Keratolytic agent
 Retinoic acid
 Skin cream
 Acanthosis nigricans
 Adolescent
 Article
 Body weight change
 Child safety
 Clinical article
 Controlled study
 Double blind procedure
 Drug efficacy
 Drug safety
 Female
 Human
 Hyperpigmentation
 Male
 Outcome assessment
 Priority journal
 Randomized controlled trial
 Acanthosis nigricans
 Child
 Comparative study
 Cutaneous drug administration
 Gel
 Neck
 Treatment outcome
 Acanthosis Nigricans
 Adapalene
 Administration, Cutaneous
 Adolescent
 Child
 Dermatologic Agents
 Double-Blind Method
 Female
 Gels
 Humans
 Keratolytic Agents
 Male
 Neck
 Skin Cream
 Treatment Outcome
 Tretinoin

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URI

https://hdl.handle.net/20.500.14740/5349

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Scopus: Year 1983-2021

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