Publication: Evaluation of Roche Abuscreen ONLINE amphetamine immunoassay for screening of new amphetamine analogues
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Issued Date
2001
Resource Type
File Type
application/pdf
ISSN
1464760
Other identifier(s)
2-s2.0-0034872340
Rights Holder(s)
Scopus
Bibliographic Citation
Journal of Analytical Toxicology. Vol 25, No.6 (2001), p.471-475
Suggested Citation
Lekskulchai V., Chintana M. Evaluation of Roche Abuscreen ONLINE amphetamine immunoassay for screening of new amphetamine analogues. Journal of Analytical Toxicology. Vol 25, No.6 (2001), p.471-475. doi:10.1093/jat/25.6.471 Retrieved from: https://hdl.handle.net/20.500.14740/6928
Author(s)
Abstract
Some structural analogues of amphetamine are now important drugs of abuse in Thailand. The utility of the Roche Abuscreen ONLINE reagent amphetamine immunoassay test kit to detect these analogues was studied. The test showed high cross-reactivity to 3,4-methylenedioxyamphetamine (MDA), but low cross-reactivity to its parent drugs, 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyethylamphetamine (MDEA), as well as to methamphetamine and ethylamphetamine. Also observed in this study was a methamphetamine detection sensitivity enhancement effect of amphetamine, which is the active metabolite of methamphetamine. Correlation between the measured concentration values and the actual amount of these two drugs in the sample was, however, low. Thus, the test can be used to detect methamphetamine only when amphetamine is also present in the sample resulting from either co-administration or metabolism of methamphetamine.