Publication:
Association between medication adherence and clinical outcomes in patients with chronic kidney disease: a prospective cohort study

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Issued Date

2017

Resource Type

Article

File Type

application/pdf

ISSN

13421751

DOI

10.1007/s10157-016-1312-6

Other identifier(s)

2-s2.0-84979300188

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Clinical and Experimental Nephrology. Vol 21, No.3 (2017), p.504-512

Suggested Citation

Tangkiatkumjai M., Walker D.-M., Praditpornsilpa K., Boardman H. Association between medication adherence and clinical outcomes in patients with chronic kidney disease: a prospective cohort study. Clinical and Experimental Nephrology. Vol 21, No.3 (2017), p.504-512. doi:10.1007/s10157-016-1312-6 Retrieved from: https://hdl.handle.net/20.500.14740/4149

Title

Association between medication adherence and clinical outcomes in patients with chronic kidney disease: a prospective cohort study

Author(s)

Tangkiatkumjai M.
 Walker D.-M.
 Praditpornsilpa K.
 Boardman H.

Abstract

Background: There is limited evidence of medication adherence related to progression of chronic kidney disease (CKD) worldwide. The aim of this study was to determine associations between medication adherence and the progression of CKD in outpatients with CKD. Methods: This cohort study recruited 339 Thai patients with stages 3–5 CKD. Patients with a glomerular disease or receiving renal replacement therapy before recruitment were excluded. 295 were followed up regarding their serum creatinine, blood pressure, glycated hemoglobin, and low-density lipoprotein cholesterol over 12 months. Medication adherence was measured at baseline using the Thai version of the 8-Item Morisky Medication Adherence Scale®. The primary outcome was the progression of CKD. The progression of CKD was defined as either a decline in estimated glomerular filtration rate of at least 3 ml/min/1.73 m2/year or initiation of renal replacement therapy. Univariate and multivariate analyses were performed using Chi-squared tests and multiple logistic regressions. Results: Twenty-one percent had poor adherence. Younger patients were more likely to have poor adherence (adjusted OR 2.81, 95 % CI 1.45–5.43). Anti-hypertensive agents were the most frequently reported as not being taken (52 %). Patients with poor adherence were associated with the progression of CKD (adjusted OR 1.96, 95 % CI 1.02–3.76). Those with poor adherence were less likely to control their blood pressure, than moderate-to-high adherence group (p < 0.01). Conclusion: The findings suggest that CKD patients with poor medication adherence are more likely to have progression of CKD. Health care providers should acknowledge these findings and provide effective strategies to deal with this issue. © 2016, Japanese Society of Nephrology.

Subject(s)

Acetylsalicylic acid
 Allopurinol
 Angiotensin receptor antagonist
 Antidiabetic agent
 Antihypertensive agent
 Antilipemic agent
 Bicarbonate
 Cyclooxygenase 2 inhibitor
 Dipeptidyl carboxypeptidase inhibitor
 Erythropoietin
 Folic acid
 Glycosylated hemoglobin
 Iron derivative
 Loop diuretic agent
 Low density lipoprotein cholesterol
 Nonsteroid antiinflammatory agent
 Phosphate binding agent
 Polystyrenesulfonate calcium
 Polystyrenesulfonate sodium
 Thiamine
 Antidiabetic agent
 Antihypertensive agent
 Antilipemic agent
 Biological marker
 Creatinine
 Glycosylated hemoglobin
 Hemoglobin A1c protein, human
 Low density lipoprotein cholesterol
 Adult
 Aged
 Anemia
 Article
 Blood pressure measurement
 Blood pressure regulation
 Chronic kidney failure
 Clinical outcome
 Cohort analysis
 Creatinine blood level
 Disease course
 Estimated glomerular filtration rate
 Female
 Human
 Hyperphosphatemia
 Major clinical study
 Male
 Medication compliance
 Prospective study
 Renal replacement therapy
 Thailand
 Blood
 Blood pressure
 Chi square distribution
 Chronic kidney failure
 Disease exacerbation
 Disorders of carbohydrate metabolism
 Drug effects
 Dyslipidemia
 Glomerulus filtration rate
 Hypertension
 Kidney
 Metabolism
 Middle aged
 Multivariate analysis
 Odds ratio
 Pathophysiology
 Risk factor
 Statistical model
 Time factor
 Treatment outcome
 Very elderly
 Aged
 Aged, 80 and over
 Antihypertensive Agents
 Biomarkers
 Blood Pressure
 Chi-Square Distribution
 Cholesterol, LDL
 Creatinine
 Disease Progression
 Dyslipidemias
 Female
 Glomerular Filtration Rate
 Glucose Metabolism Disorders
 Glycated Hemoglobin A
 Humans
 Hypertension
 Hypoglycemic Agents
 Hypolipidemic Agents
 Kidney
 Logistic Models
 Male
 Medication Adherence
 Middle Aged
 Multivariate Analysis
 Odds Ratio
 Prospective Studies
 Renal Insufficiency, Chronic
 Risk Factors
 Thailand
 Time Factors
 Treatment Outcome

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URI

https://hdl.handle.net/20.500.14740/4149

Collections

Scopus: Year 1983-2021

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