Publication:
Comparison of clinical manifestations between blepharitis patients with and without demodex infestation

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Issued Date

2019

Resource Type

Article

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application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-85068615915

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 102, No.6 (2019), p.651-656

Suggested Citation

Chanlalit W., Yodprom R., Arampinyokul P. Comparison of clinical manifestations between blepharitis patients with and without demodex infestation. Journal of the Medical Association of Thailand. Vol 102, No.6 (2019), p.651-656. Retrieved from: https://hdl.handle.net/20.500.14740/5317

Title

Comparison of clinical manifestations between blepharitis patients with and without demodex infestation

Author(s)

Chanlalit W.
 Yodprom R.
 Arampinyokul P.

Abstract

Background: Demodex mites are common ectoparasites of the skin that are implicated as a cause of blepharitis. However, it is difficult to differentiate Demodex infestation from other causes of blepharitis due to the lack of distinctive symptoms and requirement of a microscope examination to confirm the diagnosis. Objective: To compare signs and symptoms between blepharitis patients with and without Demodex infestation. Materials and Methods: Sixty-one consecutive patients with symptomatic blepharitis were enrolled. The patients completed the Ocular Surface Disease Index (OSDI) questionnaires and underwent standard eye examination, Schirmer I test, tear break-up time (TBUT), and ocular surface staining. Four eyelash samples were epilated from each eye and examined for Demodex mites using a microscope. Symptoms and signs of blepharitis between patients with and without Demodex infestation were compared. Results: The prevalence of Demodex infestation among blepharitis patients was 63.9%, with an average Demodex count of 7.2 mites per patient. Common symptoms of Demodex blepharitis included ocular irritation (82.1%), itching (79.5%), and blurry vision (76.9%), but no significant difference was found when compared to non-Demodex blepharitis. Cylindrical dandruff (CD) was significantly more prevalent in blepharitis with Demodex infestation (74.4%) than those without (22.7%) (p<0.001). TBUT was significantly shorter in the blepharitis with Demodex infestation (3.6 second) than those without (4.3) (p=0.04). There was no significant difference in age, sex, duration of symptoms, OSDI score, Schirmer I test, ocular staining score, and severity of meibomian gland dysfunction between the two groups. Conclusion: Symptoms of Demodex blepharitis are non-specific, similar to blepharitis without Demodex infestation. The presence of CD and short TBUT strongly suggest Demodex infestation and should warrant further diagnostic evaluation. © JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND | 2019.

Subject(s)

Adult
 Aged
 Article
 Blepharitis
 Blurred vision
 Clinical assessment
 Clinical feature
 Comparative study
 Cross-sectional study
 Daily life activity
 Dandruff
 Demodex
 Demodicosis
 Diagnostic accuracy
 Environmental factor
 Eye discharge
 Eye discomfort
 Eye examination
 Eye inflammation
 Eye irritation
 Eye redness
 Eyelash
 Female
 Human
 Major clinical study
 Male
 Meibomian gland dysfunction
 Ocular pruritus
 Ocular Surface Disease Index
 Parasite egg count
 Prevalence
 Schirmer test
 Slit lamp microscopy
 Tear break up test
 Trichiasis

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URI

https://hdl.handle.net/20.500.14740/5317

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Scopus: Year 1983-2021

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