Publication: Enhanced Localized Periodontitis Treatment with Azithromycin-Loaded Niosomal Thermosensitive Gels
0
0
Issued Date
2025-07-01
Resource Type
ISSN
23529520
Scopus ID
2-s2.0-105004640022
Journal Title
OpenNano
Volume
24
Rights Holder(s)
SCOPUS
Bibliographic Citation
OpenNano Vol.24 (2025)
Suggested Citation
Kerdmanee K., Thongsiri C., Supachawaroj N., Limsitthichaikoon S. Enhanced Localized Periodontitis Treatment with Azithromycin-Loaded Niosomal Thermosensitive Gels. OpenNano Vol.24 (2025). doi:10.1016/j.onano.2025.100247 Retrieved from: https://hdl.handle.net/20.500.14740/20955
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
Periodontitis is a chronic inflammatory disease requiring localized drug delivery for sustained therapeutic action. Conventional treatments face challenges such as a rapid drug clearance and poor bioavailability. This study develops and evaluates an azithromycin-loaded niosomal thermoresponsive gel (AZG) to enhance drug retention and treatment efficacy. Azithromycin-loaded niosomes (AZN) were optimized using a 32 full factorial design with Span 60 and cholesterol, achieving nanoscale size, stable zeta potential, and high drug encapsulation. The optimized AZN was incorporated into a poloxamer 407-hyaluronic acid gel, ensuring in situ gelation and prolonged drug retention. AZG exhibited favorable gelation, biocompatibility, accelerated wound closure, enhanced cell proliferation, and significant anti-inflammatory effects (twofold IL-1β and sixfold TNF-α reduction, p < 0.05). By integrating sustained drug release with antibacterial and anti-inflammatory properties, AZG presents a promising adjunctive therapy for periodontitis, addressing key limitations of existing treatments.