Publication: Cytotoxic xanthones from the roots of Mesua ferrea L.
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Issued Date
2019
Resource Type
File Type
application/pdf
ISSN
319422
Other identifier(s)
2-s2.0-85055252545
Rights Holder(s)
Scopus
Bibliographic Citation
Phytochemistry. Vol 157, (2019), p.64-70
Suggested Citation
Chukaew A., Saithong S., Chusri S., Limsuwan S., Watanapokasin R., Voravuthikunchai S.P., Chakthong S. Cytotoxic xanthones from the roots of Mesua ferrea L.. Phytochemistry. Vol 157, (2019), p.64-70. doi:10.1016/j.phytochem.2018.10.008 Retrieved from: https://hdl.handle.net/20.500.14740/5689
Abstract
Five undescribed xanthones, 4-methoxypyranojacareubin, 4-hydroxy-3-prenylpyranoxanthone, 1-hydroxy-5,7-dimethoxyxanthone, 5-hydroxy-1,6,7-trimethoxyxanthone and 2-hydroxy-1,5-dimethoxyxanthone, together with thirty-three known xanthones were isolated from the roots of Mesua ferrea L. The structures of all isolated xanthones were elucidated based on spectroscopic methods. 5-Hydroxy-1,6,7-trimethoxyxanthone and 2-hydroxy-1,5-dimethoxyxanthone were also confirmed by X-ray diffraction data. In addition, the isolated compounds were determined for antibacterial, antioxidant and cytotoxic activities. The known 1,5,6-trihydroxyxanthone showed cytotoxicity against A375, PC-3 and HaCaT cell lines with IC50 values of 5.73 μg/mL, 5.93 μg/mL and 8.94 μg/mL, respectively. © 2018 Elsevier Ltd