Publication:
Interaction between warfarin and astaxanthin: A case report

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Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

18785409

DOI

10.1016/j.jccase.2019.01.002

Other identifier(s)

2-s2.0-85061640112

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Cardiology Cases. Vol 19, No.5 (2019), p.173-175

Suggested Citation

Santiyanon N., Yeephu S. Interaction between warfarin and astaxanthin: A case report. Journal of Cardiology Cases. Vol 19, No.5 (2019), p.173-175. doi:10.1016/j.jccase.2019.01.002 Retrieved from: https://hdl.handle.net/20.500.14740/5350

Title

Interaction between warfarin and astaxanthin: A case report

Author(s)

Santiyanon N.
 Yeephu S.

Abstract

This report explains the potential interaction between warfarin and astaxanthin in a 69-year-old Thai woman with history of ischemic stroke. Before taking astaxanthin, the patient used constant doses of warfarin, atenolol, digoxin, aspirin, omeprazole, and simvastatin concomitantly for 17 days without any signs and symptoms of adverse events. One day after astaxanthin was supplemented to her treatment regimen, ecchymosis was found on the right side of her groin and thigh. On the next day, area of ecchymosis was larger. International normalized ratio (INR) values increased from 1.4 to 10.38. Warfarin and astaxanthin were withheld and vitamin K was given. Two days later, INR reduced to 1.43 and symptoms of ecchymosis were better. Causality assessment of adverse drug reaction indicated a probable relationship between bleeding symptoms and astaxanthin supplementation. Counseling the patients and caregivers as well as monitoring for potential interactions with dietary supplements should be considered as an active process in order to prevent negative outcomes to patients undergoing warfarin therapy. <Learning objective: Astaxanthin, a powerful antioxidant, has been claimed to have benefits on the cardiovascular system. The populations with high risk of atherosclerotic diseases, including patients treated with warfarin may take astaxanthin for improving their disease and overall health status. Interestingly, warfarin displays clinically significant interactions with various dietary supplements and may have potential to develop unwanted anticoagulation effects when used concomitantly with astaxanthin.> © 2019 Japanese College of Cardiology

Subject(s)

Acetylsalicylic acid
 Amiodarone
 Amlodipine
 Astaxanthin
 Atenolol
 Digoxin
 Omeprazole
 Simvastatin
 Vitamin K group
 Warfarin
 Activated partial thromboplastin time
 Adult
 Arm ecchymosis
 Article
 Bedtime dosage
 Brain ischemia
 Case report
 Clinical article
 Drug dose reduction
 Drug potentiation
 Dysarthria
 Ecchymosis
 Electrocardiography
 Essential hypertension
 Evening dosage
 Female
 Hemiparesis
 Human
 Inguinal region ecchymosis
 International normalized ratio
 Microcapsule
 Middle aged
 Morning dosage
 Persistent atrial fibrillation
 Priority journal
 Range of motion
 Swelling
 Thigh ecchymosis

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URI

https://hdl.handle.net/20.500.14740/5350

Collections

Scopus: Year 1983-2021

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