Publication:
Effect of Thunbergia laurifolia Extract on Cerebral Blood Flow in Rats

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Issued Date

2017

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-85075021757

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 100, No.10 (2017), p.S13-S18

Suggested Citation

Thongsaard W., Jariyapongskul A., Areebambud C. Effect of Thunbergia laurifolia Extract on Cerebral Blood Flow in Rats. Journal of the Medical Association of Thailand. Vol 100, No.10 (2017), p.S13-S18. Retrieved from: https://hdl.handle.net/20.500.14740/4315

Title

Effect of Thunbergia laurifolia Extract on Cerebral Blood Flow in Rats

Author(s)

Thongsaard W.
 Jariyapongskul A.
 Areebambud C.

Abstract

Background: Thunbergia laurifolia Linn. (TL) is a herbal medicine which has been used as an antidote for several poisonous agents including insecticides and as a component of a mixture of crude extracts to treat drug addicted patients. The previous study using Functional Magnetic Resonance Imaging (fMRI) technique found that oxyhemoglobin: deoxyhemoglobin increased in amygdala, caudate and nucleus accumbens by TL. These areas represent reward and addiction behavior. Objective: The present study aim to investigate the direct effect of TL (100, 200 and 300 mg/kg) on cerebral blood flow, mean arterial blood pressure, partial pressures of oxygen and carbondioxide in normal rats. Material and Method: Methanol extract of TL (100, 200 and 300 mg/kg, n = 12 in all groups) was administered intraperitoneally to rats. Cerebral blood flow, mean arterial pressure, pH, PO2 and PCO2 were measured at 5 min before, 5, 10, 20 and 30 min after injection. Results: The results showed a significant increase in cerebral blood flow and mean arterial blood pressure in a dose-related manner, but partial pressures of oxygen and carbondioxide were not affected. Conclusion: The finding explains that TL cause the increase in oxyhemiglobin: deoxyhemoglobin by increasing cerebral blood flow and mean arterial blood pressure. © 2017 Medical Association of Thailand. All rights reserved.

Subject(s)

Antidote
 Deoxyhemoglobin
 Oxyhemoglobin
 Plant extract
 Thunbergia laurifolia extract
 Unclassified drug
 Acanthaceae
 Amygdala
 Animal experiment
 Animal model
 Article
 Blood carbon dioxide tension
 Blood oxygen tension
 Brain blood flow
 Caudate nucleus
 Controlled study
 Craniotomy
 Diastolic blood pressure
 Drug dependence
 Drug dose comparison
 Drug effect
 Hemodynamics
 Laser Doppler flowmetry
 Male
 Mean arterial pressure
 Nonhuman
 Nucleus accumbens
 PH
 Rat
 Systolic blood pressure
 Thunbergia laurifolia

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URI

https://hdl.handle.net/20.500.14740/4315

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Scopus: Year 1983-2021

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