Publication:
Development of a modified 100-gram oral glucose tolerance test for diagnosis of gestational diabetes mellitus and its diagnostic accuracy

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Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-77958112410

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 93, No.10 (2010), p.1121-1127

Suggested Citation

Ruangvutilert P., Chaemsaithong P., Ruangrongmorakot K., Kanokpongsakdi S., Sunsaneevithayakul P. Development of a modified 100-gram oral glucose tolerance test for diagnosis of gestational diabetes mellitus and its diagnostic accuracy. Journal of the Medical Association of Thailand. Vol 93, No.10 (2010), p.1121-1127. Retrieved from: https://hdl.handle.net/20.500.14740/7667

Title

Development of a modified 100-gram oral glucose tolerance test for diagnosis of gestational diabetes mellitus and its diagnostic accuracy

Author(s)

Ruangvutilert P.
 Chaemsaithong P.
 Ruangrongmorakot K.
 Kanokpongsakdi S.
 Sunsaneevithayakul P.

Abstract

Objective: To develop a modified 100-g oral glucose tolerance test (100-g OGTT) for the diagnosis of gestational diabetes mellitus (GDM) in order to reduce the number of values needed for the test. Materials and Methods: Patient charts of pregnant women who completed the 100-g OGTT test at the antenatal clinic, Siriraj Hospital between 2005 and 2006 were reviewed. Cases diagnosed with GDM using standard 100-g OGTT were selected. In non-GDM cases, the last 100-g OGTT test was selected. Diagnostic performances of each glucose value and two or three values in various combinations were determined. Results: One thousand seven hundred sixty three women completed GDM diagnosis throughout their pregnancy. Four hundred three women had GDM while 1,360 subjects were non-GDM. Considering single glucose values, the highest level of accuracy, and the best ROC curve were obtained from the value at 2 hours after glucose ingestion (2-h glucose value) with 93.00% accuracy and the area under the ROC curve of 0.961. The combination of 2-h glucose value with fasting plasma glucose (FPG) showed 93.25% accuracy. FPG combined with 1-h and 2-h glucose values achieved 100% sensitivity with 92% accuracy. Conclusion: FPG in combined with 1-h and 2-h glucose values is an interesting alternative for the diagnosis of GDM.

Subject(s)

Article
 Diagnostic accuracy
 Diagnostic value
 Female
 Glucose blood level
 Human
 Major clinical study
 Oral glucose tolerance test
 Pregnancy diabetes mellitus
 Sensitivity and specificity
 Analysis
 Blood
 Diabetes, Gestational
 Diagnostic error
 Evaluation study
 Gestational age
 Glucose tolerance test
 Pregnancy
 Procedures
 Receiver operating characteristic
 Reproducibility
 Retrospective study
 Risk
 Glucose blood level
 Blood Glucose
 Diabetes, Gestational
 Diagnostic Errors
 Female
 Gestational Age
 Glucose Tolerance Test
 Humans
 Pregnancy
 Reproducibility of Results
 Retrospective Studies
 Risk
 ROC Curve

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URI

https://hdl.handle.net/20.500.14740/7667

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Scopus: Year 1983-2021

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