Publication:
Neuropeptide y in the adult and fetal human pineal gland

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Issued Date

2014

Resource Type

Article

File Type

application/pdf

ISSN

23146133

DOI

10.1155/2014/868567

Other identifier(s)

2-s2.0-84897487309

Rights Holder(s)

Scopus

Bibliographic Citation

BioMed Research International. Vol 2014, (2014)

Suggested Citation

Møller M., Phansuwan-Pujito P., Badiu C. Neuropeptide y in the adult and fetal human pineal gland. BioMed Research International. Vol 2014, (2014). doi:10.1155/2014/868567 Retrieved from: https://hdl.handle.net/20.500.14740/6455

Title

Neuropeptide y in the adult and fetal human pineal gland

Author(s)

Møller M.
 Phansuwan-Pujito P.
 Badiu C.

Abstract

Neuropeptide Y was isolated from the porcine brain in 1982 and shown to be colocalized with noradrenaline in sympathetic nerve terminals. The peptide has been demonstrated to be present in sympathetic nerve fibers innervating the pineal gland in many mammalian species. In this investigation, we show by use of immunohistochemistry that neuropeptide Y is present in nerve fibers of the adult human pineal gland. The fibers are classical neuropeptidergic fibers endowed with large boutons en passage and primarily located in a perifollicular position with some fibers entering the pineal parenchyma inside the follicle. The distance from the immunoreactive terminals to the pinealocytes indicates a modulatory function of neuropeptide Y for pineal physiology. Some of the immunoreactive fibers might originate from neurons located in the brain and be a part of the central innervation of the pineal gland. In a series of human fetuses, neuropeptide Y-containing nerve fibers was present and could be detected as early as in the pineal of four- to five-month-old fetuses. This early innervation of the human pineal is different from most rodents, where the innervation starts postnatally. © 2014 Morten Møller et al.

Subject(s)

Neuropeptide Y
 Neuropeptide Y
 Adult
 Aged
 Article
 Child
 Controlled study
 Fetus
 Human
 Human tissue
 Immunohistochemistry
 Nerve fiber
 Neurophysiology
 Parasympathetic innervation
 Pineal body
 Pinealocyte
 Very elderly
 Adolescent
 Animal
 Cytology
 Embryology
 Female
 Male
 Metabolism
 Middle aged
 Pineal body
 Rodent
 Species difference
 Adolescent
 Adult
 Aged
 Aged, 80 and over
 Animals
 Child
 Female
 Fetus
 Humans
 Male
 Middle Aged
 Nerve Fibers
 Neuropeptide Y
 Pineal Gland
 Rodentia
 Species Specificity

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URI

https://hdl.handle.net/20.500.14740/6455

Collections

Scopus: Year 1983-2021

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