Publication:
Middle cerebral artery peak systolic velocity in fetuses with homozygous alpha-thalassemia-1: Case series

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Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-79952269419

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 93, No.SUPPL 2 (2010), p.S114-S117

Suggested Citation

Raungrongmorakot K., Chaemsaithong P. Middle cerebral artery peak systolic velocity in fetuses with homozygous alpha-thalassemia-1: Case series. Journal of the Medical Association of Thailand. Vol 93, No.SUPPL 2 (2010), p.S114-S117. Retrieved from: https://hdl.handle.net/20.500.14740/7459

Title

Middle cerebral artery peak systolic velocity in fetuses with homozygous alpha-thalassemia-1: Case series

Author(s)

Raungrongmorakot K.
 Chaemsaithong P.

Abstract

Objectives: The objective of this study is to evaluate the potential usefulness of middle cerebral artery peak systolic velocity (MCA-PSV) as a non-invasive means of detecting an anemic fetus from homozygous alphathalassemia- 1 Material and Method: We observed four cases of referrals with complicated pregnancies in which the fetuses were suspected with homozygous alpha-thalassemia-1. Three out of four cases involved hydrop fetalis, detected through previous ultrasounds, while the remaining case was referred for prenatal diagnosis. Subsequently, we performed a detailed ultrasound and fetal MCA-PSV in all cases, and to confirm the diagnosis, we also performed cordocentesis. Results: With all the four cases having the gestational age range from 18 to 27 weeks, three showed hydrop fetalis. The remaining case, the 18-week gestational age fetus referred for prenatal diagnosis, showed an increase in the cardiothoracic ratio without other signs of hydrop fetalis. MCA-PSV suggested the presence of fetal anemia in all cases (with the velocity ranging from 37.3 to 62.2 cm/sec). The results obtained from cordocentesis confirmed fetal anemia and homozygous alpha-thalassemia-1 in all cases. Conclusion: Peak systolic velocity of fetal middle cerebral artery can predict anemia in fetus affected with homozygous alpha-thalassemia-1 disease.

Subject(s)

Alpha thalassemia
 Article
 Blood flow velocity
 Brain circulation
 Case report
 Cordocentesis
 Echography
 Female
 Fetus
 Fetus echography
 Genetics
 Gestational age
 Homozygote
 Human
 Methodology
 Middle cerebral artery
 Pathophysiology
 Physiology
 Placenta
 Predictive value
 Pregnancy
 Systole
 Alpha-Thalassemia
 Blood Flow Velocity
 Cerebrovascular Circulation
 Cordocentesis
 Female
 Fetus
 Gestational Age
 Homozygote
 Humans
 Middle Cerebral Artery
 Placenta
 Predictive Value of Tests
 Pregnancy
 Systole
 Ultrasonography, Prenatal

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URI

https://hdl.handle.net/20.500.14740/7459

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Scopus: Year 1983-2021

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